Background Pyrethroids are commonly used as insecticides for both household and agricultural applications, and have recently been linked to endocrine disruption. Cypermethrin is a type П pyrethroid which is used widely throughout the world. The present study was aimed to investigate the effects of cypermethrin on the sexual behaviour and plasma level of pituitary-gonadal hormones of adult male ...

Mouse CYP2J5 is abundant in kidney and active in the metabolism of arachidonic acid to epoxyeicosatrienoic acids. Western blots of microsomes prepared from mouse kidneys demonstrate that after puberty, CYP2J5 protein is present at higher levels in male mice than in female mice. Northern analysis reveals that CYP2J5 transcripts are more abundant in adult male versus female kidneys, indicating th...

The experimental carcinogenesis results in six compounds related to vinyl chloride are reported. Vinylidene chloride, given by inhalation, was carcinogenic in male CD-1 mice, male CD rats, Sprague-Dawley rats and male Swiss mice. Trichloroethylene, given by gavage and inhalation, was carcinogenic in the B6C3F1 mice. When given by gavage, perchloroethylene was carcinogenic in the B6C3F1 mice, an...

We examined the hypothesis that contraction of the carotid arteries to serotonin is normally inhibited by endothelial NO synthase (eNOS) and is enhanced in mice lacking the gene for eNOS. Because the influence of eNOS may vary with the sex of the mouse, we also tested whether responses to serotonin were dependent on sex. We studied carotid arteries in vitro from littermate control (eNOS(+/+)) m...

introduction: the origin of neonatal oocyte development is unknown. however, estrogen plays an essential role during development of the female reproductive system. anastrozole is used as both ovulation stimulating and an anticancer drug. the aim of this study was to evaluate the impact of anastrozole on follicular development and differentiation in mice. materials and methods: in the present st...

herbal medicine has an old history with a broad application all over the world. many researches have focused on the curative as well as antinociceptive effects of herbal extract. the aim of this study was to investigate the analgesic effects of berberis vulgaris hydroethanolic extract (bve) in male mice. 30 male mice were divided into 5 groups: control, treated by morphine, treated by bve (150 ...

The mechanism by which acetaminophen (APAP) causes liver damage evokes many aspects drug metabolism, oxidative chemistry, and genetic-predisposition. In this study, we leverage the relative resistance of female C57BL/6 mice to APAP-induced liver damage (AILD) compared to male C57BL/6 mice in order to identify the cause(s) of sensitivity. Furthermore, we use mice that are either heterozygous (HZ...

Noni (Morinda citrifolia L.) is one of the many herbs which known as an anticancer agent. Nanoencapsulated form noni extracts could help body absorption and able to inhibit proliferation cancer cells in vitro. This study was conducted examine activity nanoencapsulated vivo anti-proliferation agent cells. extract obtained by maceration method using water a solvent. The nanocapsule made ionic gel...

Testosterone deficiency is commonly observed in male patients with chronic obstructive pulmonary disease (COPD), which characterized by inflammation of the airways and emphysema. Although clinical trials have indicated that testosterone replacement therapy can improve respiratory function COPD, role pathogenesis COPD remains unclear. The aim this study was to explore effect on development emphy...