C hronic lung diseases (CLDs), including chronic obstructive pulmonary disease (COPD), asthma, lung cancer, interstitial lung disease and pulmonary hypertension, present a significant and rising global health problem. CLDs develop at the interface between genetic susceptibilities and environmental aspects, and are currently the second leading cause of death worldwide. Thus far, therapies of onl...

Lung transplantation offers a lifesaving therapy for patients with end-stage lung disease but its availability is presently limited by low organ utilization rates donor lungs frequently excluded due to unsuitability at assessment. When does occur, recipients are then vulnerable primary graft dysfunction (PGD), multitudinous short-term complications, and chronic allograft dysfunction. The decisi...

introduction: the respiratory system is both a route of entry and exit for toxins and injurious agents, as well as being a target for chemical substances and pathogens. therefore, an understanding of the structure and function of the migratory cell populations of pulmonary tissues including alveolar macrophages is central in a number of important disease processes. this study aimed to identify ...

The intensity and type of trauma inflicted on a bod y by blast overpr essure are related to man y facto rs. Among them, body orientation. In order to study the effect of body orientation, detailed models of 2D horizontal slices of human and sh eep thoraces have been developed and va lidated with the limited data available in the open literature. The main goal o f this stud y is to verify if the...

lung exposure to sulfur mustard (sm) results in pulmonary complications, which is the main cause of long-term disability and morbidity. up to now, the precise mechanisms of sm-induced lung complications has not been identified. the aim of this study was to evaluate apoptosis in the lung tissue of sm-exposed individuals. the study was performed on archived lung paraffin-embedded tissue specimens...

Bomb blast injuries are no longer confined to battlefields. With the ever present threat of terrorism, we should always be prepared for bomb blasts. Bomb blast injuries tend to affect air-containing organs more, as the blast wave tends to exert a shearing force on air-tissue interfaces. Commonly-injured organs include the tympanic membranes, the sinuses, the lungs and the bowel. Of these, blast...

OBJECTIVE Sulfur mustard (SM) is a potent mutagenic agent that targets several organs, particularly lung tissue. Changes in morphological structure of the airway system are associated with chronic obstructive pulmonary deficiency following exposure to SM. Although numerous studies have demonstrated pathological effects of SM on respiratory organs, unfortunately there is no effective treatment t...

Method From 1995-2014, 20 patients were operated for bronchial rupture due to blunt chest trauma. Of these, 7 had complex bronchial injuries (3 located in the right bronchial tree, 3 in the left bronchial tree and 1 had a rupture of both, right and left main bronchi). Injuries to the trachea and simple single bronchial ruptures (within 2.5-3 cm from the carina on the left, and within 1 cm on th...