β-Lactone natural products occur infrequently in nature but possess a variety of potent and valuable biological activities. They are commonly derived from β-hydroxy-α-amino acids, which are themselves valuable chiral building blocks for chemical synthesis and precursors to numerous important medicines. However, despite a number of excellent synthetic methods for their asymmetric synthesis, few ...

An investigation was carried out on the effect of some amino acids on the growth and production of Lglutamic acid by a mutant Micrococcus glutamicus AB100 using selected suitable synthetic medium. It was observed that among different amino acids studied, l-alanine, l-arginine, l-threonine, l-tryptophan, l-proline and l-hitidine had positive effect; l-leucine, l-valine, l-phenylalanine, l-serine...

We found that the simple addition of L-methionine to the wild type of Corynebacterium glutamicum results in excretion of the cellular building block L-lysine up to rates of 2.5 nmol/min/mg (dry weight). Biochemical analyses revealed that L-methionine represses the homoserine dehydrogenase activity and reduces the intracellular L-threonine level from 7 to less than 2 mM. Since L-lysine synthesis...