نتایج جستجو برای: ku70

تعداد نتایج: 763  

2002
Danyelle M. Townsend Hongxie Shen Alexandra L. Staros Laurent Gaté Kenneth D. Tew

Human ovarian carcinoma cells (C70 and C200) made resistant to cisplatin from A2780 cells demonstrated an 20-fold resistance to the drug. These same cell lines showed no collateral resistance (as compared with the wild-type) to a novel glutathione S-transferase activated prodrug { -glutamyl-amino[2-ethylN,N,N ,N -tetrakis (2-chloroethyl) phosphorodiamidate]sulfonyl-propionyl-(R)-( ) phenylglyci...

Journal: :Molecular cancer therapeutics 2016
Hong-Yi Chang Ting-Chia Chang Wen-Ya Huang Chung-Ta Lee Chia-Jui Yen Yuh-Shyan Tsai Tzong-Shin Tzai Shu-Hui Chen Nan-Haw Chow

Tumor hypoxia is associated with radioresistance, chemoresistance, and metastasis, which eventually lead to cancer progression and a poor patient prognosis. RON [also known as macrophage-stimulating protein receptor (MST1R)] belongs to the c-MET [also known as hepatocyte growth factor receptor (HGFR)] receptor tyrosine kinase (RTK) superfamily. To identify the interaction partners of RON nuclea...

Journal: :Nucleic Acids Research 2005
Nicholas S. Y. Ting Yaping Yu Brant Pohorelic Susan P. Lees-Miller Tara L. Beattie

Maintenance of telomere integrity requires the dynamic interplay between telomerase, telomere-associated proteins and DNA repair proteins. These interactions are vital to suppress DNA damage responses and changes in chromosome dynamics that can result in aneuploidy or other transforming aberrations. The interaction between the DNA repair protein Ku and the RNA component of telomerase (TLC1) in ...

Journal: :Journal of radiation research 2004
Manabu Koike Aki Koike

The Ku protein is a complex of two subunits, Ku70 and Ku80, and it plays a role in multiple nuclear processes, e.g., nonhomologous DNA-end-joining (NHEJ), chromosome maintenance, and transcription regulation. On the other hand, several studies have reported a cytoplasmic or cell surface localization of Ku in various cell types. The mechanism underlying the regulation of all the diverse function...

Journal: :Journal of cell science 2005
Sahar Sibani Gerald B Price Maria Zannis-Hadjopoulos

One of the functions of the abundant heterodimeric nuclear protein, Ku (Ku70/Ku80), is its involvement in the initiation of DNA replication through its ability to bind to chromosomal replication origins in a sequence-specific and cell cycle dependent manner. Here, using HCT116 Ku80+/- cells, the effect of Ku80 deficiency on cell cycle progression and origin activation was examined. Western blot...

Journal: :Molecular medicine reports 2008
Emanuela Marras Petra Willems Veerle Vandersickel Isabella Ceriani Hubert Thierens Anne Vral Gianpaolo Perletti

Previous results from our research group have shown that the c.-1310 C↷G single nucleotide polymorphism in the promoter region of the XRCC6/Ku70 gene is significantly associated with breast cancer in a sample human patient population. In an attempt to attribute a functional meaning to this polymorphism, we performed a thorough analysis using a number of established in silico tools that strongly...

Journal: :Journal of Biological Chemistry 2001

Journal: :The Journal of Experimental Medicine 2010

2012
Laura Näätsaari Beate Mistlberger Claudia Ruth Tanja Hajek Franz S. Hartner Anton Glieder

Targeted gene replacement to generate knock-outs and knock-ins is a commonly used method to study the function of unknown genes. In the methylotrophic yeast Pichia pastoris, the importance of specific gene targeting has increased since the genome sequencing projects of the most commonly used strains have been accomplished, but rapid progress in the field has been impeded by inefficient mechanis...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
Y Gu J Sekiguchi Y Gao P Dikkes K Frank D Ferguson P Hasty J Chun F W Alt

Mammalian nonhomologous DNA end joining employs Ku70, Ku80, DNA-dependent protein kinase catalytic subunit (DNA-PKcs), XRCC4, and DNA ligase IV (Lig4). Herein, we show that Ku70 and Ku80 deficiency but not DNA-PKcs deficiency results in dramatically increased death of developing embryonic neurons in mice. The Ku-deficient phenotype is qualitatively similar to, but less severe than, that associa...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید