نتایج جستجو برای: janus kinase 2
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Accumulating evidence suggests that proteins tethered to the plasma membrane through glycosylphosphatidylinositol (GPI) anchors share common biological properties. In the present study we demonstrate that GPI-anchored proteins regulate T cell growth. Specifically, anti-TCR-induced proliferation was profoundly inhibited by co-immobilized mAb specific for Thy-1, CD48 and Ly6A/E. However, neither ...
Recombinant human erythropoietin is widely used to treat anemia associated with cancer and with the myelosuppressive effects of chemotherapy, particularly platinum-based regimens. Erythropoietin is the principal regulator of erythroid cell proliferation, differentiation, and apoptosis. Recently, the antiapoptotic and proliferative effects of erythropoietin on nonhematopoietic cells were also es...
Janus Kinase 2 Determinants for Growth Hormone Receptor Association, Surface Assembly, and Signaling
This work describes the synthesis and cytotoxic evaluation of thiophene thienopyrimidine derivatives. The investigated compound was subjected to target prediction that indicated its high affinity kinases Janus kinase 2 (JAK2) specifically. Molecular docking screening performed on three different JAK2 proteins downloaded from Protein Data Bank (PDB: 5AEP, 4C62 3ZMM). In vitro inhibitory activity...
The article presents the results of a review publications devoted to study problems drug-induced liver damage in inflammatory bowel diseases (IBD). hepatotoxic effect thiopurines (azathioprine and 6-mercaptopurine) — hepatotoxicity from 0% 17%; sulfasalazine mesalamine (hepatotoxicity 4%); methotrexate 15% 50%); tumor necrosis factor inhibitors up 75% cases.), anti-integrins 2% 5%); an interleu...
During Drosophila oogenesis the follicular epithelium becomes subdivided into distinct cell populations. New reports have established that the Janus kinase (JAK) signalling pathway plays an important role in this process.
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