Recent discoveries have highlighted the influence of host genomics on hepatitis C virus (HCV) infection outcomes. As a result, our views on hepatitis C pathogenesis and therapeutic approaches have been transformed. The recognition of the impact of single-nucleotide polymorphisms (SNPs) of the genes interleukin 28B (IL28B), inosine triphosphatase (ITPA) and low-density lipoprotein cholesterol re...

Energetic particle (EP) driven instabilities will be of strongly increased relevance in future burning plasmas as the EP pressure very large compared to thermal plasma. Understanding interaction EPs and bulk plasma is crucial for developing next-generation fusion devices. In this work, JOREK MHD code extended allow simulation at high pressures using realistic parameter a full-f formulation with...

The confinement of energetic particles (EPs) is crucial in the efficient heating of tokamak plasmas. Plasma instabilities such as Alfvén eigenmodes (AEs) can redistribute the EP population, making the plasma heating less effective and leading to additional loads on the walls. The nonlinear dynamics of toroidicity induced AEs (TAEs) is investigated by means of the global gyrokinetic particle-in-...