Ipsilateral retinal projections (IRP) in the optic chiasm (OC) vary considerably. Most animal groups possess laterally situated eyes and no or few IRP, but, e.g., cats and primates have frontal eyes and high proportions of IRP. The traditional hypothesis that bifocal vision developed to enable predation or to increase perception in restricted light conditions applies mainly to mammals. The eye-...

Changes in iron homeostasis have been implicated in cardiotoxicity induced by the anticancer anthracycline doxorubicin (DOX). Certain products of DOX metabolism, like the secondary alcohol doxorubicinol (DOXol) or reactive oxygen species (ROS), may contribute to cardiotoxicity by inactivating iron regulatory proteins (IRP) that modulate the fate of mRNAs for transferrin receptor and ferritin. I...

Persistent homology provides a new approach for the topological simplification of big data via measuring the life time of intrinsic topological features in a filtration process and has found its success in scientific and engineering applications. However, such a success is essentially limited to qualitative data classification and analysis. Indeed, persistent homology has rarely been employed f...

Persistent homology provides a new approach for the topological simplification of big data via measuring the life time of intrinsic topological features in a filtration process and has found its success in scientific and engineering applications. However, such a success is essentially limited to qualitative data characterization, identification and analysis (CIA). Indeed, persistent homology ha...

Endohedral metallofullerene species with controllable electron spin have attracted increasing attention along with their potential application in quantum information processing. In this paper, we report the electron spin manipulation via encage cluster through comparative studies on the anion radicals of metallofullerene Y2@C82-Cs, Y2C2@ C82-Cs, and Sc2C2@C82-Cs. Although these three radical sp...

Iron regulates mRNA translation initiation through RNA iron responsive element (IRE) By Jia Ma Advisor: Professor Dixie J. Goss The non-coding IRE-RNA structure, a 30 nt stem loop structure, regulates synthesis of proteins in iron trafficking, cell cycling, and nervous system function. IRE-RNA binding with iron regulatory protein (IRP) proteins inhibits ribosome accessing mRNA. Increasing iron ...

Gadolinium endohedral metallofullerenes (EMFs) have shown the potential to become next generation magnetic resonance imaging (MRI) contrast agents due to their significantly improved efficiency and safety, as well as multi-day body retention which allows for a longer surgery and observation compared to current contrast agents. In Chapter 1, I have reviewed the development of gadolinium EMF base...

It is commonly proposed that the number of fibers that do not cross in the optic chiasm (OC) is proportional to the size of the binocular visual field, and that the major advantage of binocular vision is acute depth perception. I present an alternative, an 'eye-forelimb' (EF) hypothesis, suggesting that alterations in the OC influence the length of neural pathways that transmit visual informati...

I read with interest the recent article by Zoltan et al. (1) regarding the use of an algorithm for testing and reporting serum choriogonadotropin at clinically significant decision levels with use of “pregnancy test” reagents. They stated that all human choriogonadotropin (hCG) concentrations (except where noted) were reported in WHO First International Preparation (1st IRP) units. However, whe...