INTRODUCTION Microalbuminuria in type 1 diabetes is the earliest manifestation of diabetic microangiopathy (nephropathy). To date, the pharmacological approach to microangiopathy has not been shown to be useful. By using aminaphtone to control nephrologic complications of insulin-dependent diabetes mellitus we first obtained a significant improvement in microalbuminuria confirming this new phar...

OBJECTIVE Type 2 diabetes is associated with defects in insulin secretion and insulin action. Hyperglycemia may aggravate these defects, a feature known as glucose toxicity. Previous studies have shown that acute correction of hyperglycemia in subjects with long-standing type 2 diabetes gives only short-term improvement in glycemic control after discontinuation of insulin. The current study att...

Insulin therapy is likely to change within the next decade. Inhaled insulin is likely to be marketed within a year. Buccal insulin also shows promise. Oral insulin therapy is in a nascent phase but holds promise. Nasal and dermal insulin formulations are also being experimented with.

The article is a summary of personal experience and literature data from PubMed, Scopus, Web Science, ClinicalTrials.gov databases. As result the analysis, main problems faced by practical endocrinologists when administering insulin therapy to patients with type 2 diabetes mellitus (T2DM) have been determined. Insulin remains an important component glucose-lowering in T2DM. A significant increa...

Maturity onset diabetes of the young (MODY) is a relatively young-onset mellitus with an autosomal dominant inheritance. Among these phenotypes, MODY3, caused by mutations in HNF1A, one most frequent. Although MODY3 known to respond markedly sulfonylureas (SU), many cases require insulin therapy. However, there are no clear guidelines for factors consider when introducing antidiabetic drugs and...

objective: metabolic side effects of the second generation (atypical) antipsychotics have been a forefront of attention since their availability. one common   concern   is   the   development   of   hyperglycemia   and   insulin resistance. the aim of this study was to evaluate the effect of early initiation of omega-3 fatty acids supplementation on glucose-insulin homeostasis in a group of psy...

BACKGROUND Intensive insulin therapy has been found to reduce mortality in some critically ill patients. We performed a systematic review and meta-analysis to ascertain the effect of intensive insulin therapy on the incidence of acute kidney injury (AKI) in adult critically ill patients. METHODS We searched MEDLINE, SCOPUS and the Cochrane Central Register of Controlled Trials for studies tha...

Basal insulin therapy can improve glycemic control in people with type 2 diabetes. However, timely initiation, optimal titration, and proper adherence to prescribed basal insulin regimens are necessary to achieve optimal glycemic control. Even so, glycemic control may remain suboptimal in a significant proportion of patients. Unique circumstances in Asia (eg, limited resources, management of di...