نتایج جستجو برای: immune mediated disease
تعداد نتایج: 2013882 فیلتر نتایج به سال:
IgG4-related disease (IgG4-RD) is a rare immune-mediated condition associated with fibro-inflammatory lesions. It was first recognized as distinct in 2003 [1,2]. of middleaged patients, mean age at diagnosis approximately 60 years old that predominates men [1]. often presents multiorgan occurring synchronous or metachronous fashion tendency to form tumor-like lesions almost every organ system
Background: Cell mediated immunity, especially cytotoxic T cell responses against HIV-1 infection, plays a critical role in controlling viral replication and disease progres-sion. DNA vaccine is a novel technology which is known to stimulate strong cellular immune responses. Many DNA vaccines have been tested for HIV infection but there is still no effective vaccine against this infection. Cons...
The presence of autoantibodies usually precedes autoimmune disease, but is sometimes considered an incidental finding with no clinical relevance. The prevalence of immune-mediated diseases was studied in a group of individuals from the Estonian Genome Project (n = 51,862), and 6 clinically significant autoantibodies were detected in a subgroup of 994 (auto)immune-mediated disease-free individua...
Abstract Dysregulated humoral immune mechanisms result in immunoglobulin production that is pathogenic and contributes to a wide range of autoimmune diseases transplant rejection. Proteases derived from human pathogens can specifically cleave these immunoglobulins (Ig) potentially eliminate circulating, cell-surface immune-complex Ig classes modulate Ig-mediated autoimmunity inflammation, provi...
Objectives: Immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disease characterized by thrombocytopenia. This review will examine the Notch-aromatic hydrocarbon receptor (AhR)-interleukin-22 (IL-22) signaling pathway regulatory mechanisms in ITP to generate ideas for pathogenesis and etiological investigation of disease. Mechanism: Studies had shown that abnormal imbalance immune...
multiple sclerosis (ms) is a neuroinflammatory autoimmune disease which mediated by various molecular and cellular immune components however recent reports have shown that coagulation factors that traditionally separate from the immune system might also be involved in ms development and progression.studies on experimental autoimmune encephalomyelitis (eae) and human ms patients reports alterati...
experimental autoimmune encephalomyelitis (eae) is a mouse model for multiple sclerosis (ms), this autoimmune disease is mainly mediated by adaptive and innate immune responses that lead to an inflammatory demyelination and axonal damage. imatinib mesylate is a selective protein tyrosine kinase inhibitor with immunomodulatory properties that abrogates multiple signal transduction p...
Zataria multiflora essential oil possesses immunomodulatory effects and the present study investigatesits effect on immune responses to live Newcastle disease (ND) vaccines and faecal shedding period ofvaccine strain virus in chickens. One hundred and eighty chickens from both sexes were divided into 6 equalgroups: group 1: unvaccinated, group 2: vaccinated (B1 vaccine followed by La Sota 10 da...
conclusions in conclusion, pegfp-kmp-gp96 (fusion) induced th1 platform immune response against leishmania major (mrho/ir/75/er) infection. results according to the results, the level of cytokines interferon-gamma (ifn-γ) and interleukin (il)-4, and ratio of ifn-γ /il4 was changed among different groups of mice before and seven weeks after immunization. the cytokines were increased significantl...
conclusions acute hev infection shows a pattern of th1-type immune response, and the direct significant positive correlation between the serum level of scd26 and ifn-γ in acute hev infected patients, suggests that the trend of scd26 levels is a valuable marker for predicting hepatic inflammation in hepatitis e. results the results showed a significant difference in ifn-γ and scd26 (p < 0.0001 a...
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