Abstract Dysregulated humoral immune mechanisms result in immunoglobulin production that is pathogenic and contributes to a wide range of autoimmune diseases transplant rejection. Proteases derived from human pathogens can specifically cleave these immunoglobulins (Ig) potentially eliminate circulating, cell-surface immune-complex Ig classes modulate Ig-mediated autoimmunity inflammation, provi...

Respiratory diseases, always being a threat towards the health of people all over the world, are most tightly associated with immune system. Neutrophils serve as an important component of immune defense barrier linking innate and adaptive immunity. They participate in the clearance of exogenous pathogens and endogenous cell debris and play an essential role in the pathogenesis of many respirato...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 the physical interaction of proteins which lead to compiling them into large densely connected networks is a noticeable subject to investigation. protein interaction networks are useful because of making basic scientific abstraction and improving biological and biomedical applications. based on principle roles of proteins ...

The defense of the respiratory system against infection involves a complex interplay of the humoral immune system and the cellular immune system with complement and phagocytic cells. The respiratory tract is an important portal of entry for infection, and it is therefore not surprising that many immune deficiencies present initially with a respiratory infection. Thus, pediatric pulmonologists m...

human t lymphotropic virus type i (htlv-i) is a retrovirus which is associated with adult t cells leukaemia (atl) and htlv-i-associated myelopathy/tropical spastic paraparesis (ham/tsp) in a minority of htlv-i-infected individuals. it is not clear why a minority of htlv-i-infected individuals develop ham/tsp and majority remains lifelong carriers. it seems that the interaction between the virus...

Fas-mediated apoptosis contributes to physiological and pathological cellular processes, such as differentiation and survival. In particular, the roles of Fas in immune cells are complex and critical for the maintenance of immune tolerance. The precise pathways and unique functions associated with Fas/FasL-mediated signaling in the immune system are known. The dual character of Fas/FasL-mediate...

age-related macular degeneration (amd) is the leading cause of blindness in old subjects. it is a multifactorial disease with both environmental and genetic factors playing some role in its pathogenesis. similar to many other genetic diseases, the inheritance pattern of amd does not fit into simple mendelian rules. these diseases are caused by the presence of multiple genetic factors and are ca...

Background and Purpose: Chronic granulomatous disease (CGD) is an inherited disorder of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. This disorder results in recurrent life-threatening bacterial and fungal infections. Aspergillus species are the most common fungal infections in these patients. Case Report: Herein, we present a case of fungal infection in a girl wi...

Aging is a complex phenomenon leading to numerous changes in the physiological systems of the body. One of the most important changes, called immunosenescence, occurs in the immune system. Immunosenescence covers changes in the innate and the adaptive immune systems and is associated with a low-grade inflammation called inflammaging. Aging, likely via inflammaging, is also associated with the e...