BACKGROUND AND AIMS Recently, controversial results have been reported regarding the association of the polymorphisms of platelet membrane glycoproteins (HPA-2a/b, GP VI T13254C, and GP Ibα VNTR) with coronary artery disease (CAD). We performed this meta-analysis to further assess the polymorphisms of platelet membrane glycoproteins with a risk of CAD. METHODS A systematic electronic literatu...

background: preeclampsia is a pregnancy complication with unknown etiology and its incidence is associated with genetic and environmental factors. there are inconsistent reports related to the role of endothelial nitric oxide synthase (enos) 4a/b polymorphism on the risk of preeclampsia development. the aim of the present study was to investigate the possible influence of enos 4a/b and its syne...

The ABO histo-blood group, the critical determinant of transfusion incompatibility, was the first genetic polymorphism discovered in humans. Remarkably, ABO antigens are also polymorphic in many other primates, with the same two amino acid changes responsible for A and B specificity in all species sequenced to date. Whether this recurrence of A and B antigens is the result of an ancient polymor...

background il28b polymorphism is recognized as one of the most prominent predictors of hepatitis c spontaneous and treatment-induced clearance. interestingly, the favorable genotypes of il28b are found to be more frequent in asian ethnicity than caucasian and african populations, respectively. a few studies reported that there is a mysterious association between the il28b polymorphism and the h...

patients and methods this cross - sectional study was conducted on 143 thalassemic patients with chronic hepatitis c, who were treated with a combination of peg-ifn and rbv regimen. the rs12979860 and rs8099917 polymorphisms were assessed as the most common polymorphisms near the il28b gene by the polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) method. objectives w...

background it has been found that itpase deficiency is caused by itpa gene polymorphisms. it was observed that itpa polymorphisms have impact on hematological changes, including hemoglobin (hb)-decline during treatment of chronic hepatitis c (chc) patients with pegylated-interferon (peg-ifn) plus ribavirin (rbv). conclusions in patients with chc, who were treated with peg-ifn plus rbv, hb-decli...

background and objective: host genetic factors such as cytokine gene polymorphisms as well as helicobacter pylori (h. pylori) infection have been found to be associated with gastric cancer risk . interleukin 1 is a pro-inflammatory cytokine involved in h. pylori-induced gastric inflammation. therefore, we analyzed the association between il-1β and il-1-rn polymorphisms and gastric cancer in per...

chamomile (matricaria chamomilla), an important medicinal plant belonging to the asteraceae family,has a wide distribution in iran and other parts of the world. the medicinal and pharmacological effects ofchamomile are mainly associated with its essential oil content and it is widely used in food, cosmetics andpharmaceutical industries. despite its wide geographical distribution in iran, little...

introduction: a factor known to cause thrombophilia in women with recurrent pregnancy loss (rpl) is the a1298c polymorphism of methylenetetrahydrofolate reductase gene (mthfr). this study aimed to determine the association between rpl and this polymorphism in iranian patients. methods: in this case-control study, 30 patients with a previous history of two or more consecutive unexplained abortio...

results genotype frequencies of g/a in fertile and infertile men were significantly different (χ2 = 4.16, df = 1, p = 0.041). genotype frequencies of g/g and a/ain fertile and infertile men were not significantly different (χ2 = 3.32, df = 1, p = 0.068 and χ2 = 0.521, df = 1, p = 0.47, respectively). the risk of infertility was 1.43 folds higher in individuals with the a/a genotype compared to ...