We aimed in this study to determine the changes due to hyperthyroidism or hypothyroidism in serum ferritin, iron, transferrin, vitamin Bn and erythrocytic parameters and to investigate the interrelationships between these parameters .Serum ferritin, iron, total iron-binding capacity (transferrin), vitamin B12, total andfree trüodothyronine (TT3 and FT3) , total andfree thyroxine (TT4 and FT4), ...

Sir, I read with interest the article by Tindall, Griffiths & Penn.' They conclude that 'scintigraphy has been shown to be of little practical value in... patients with hypothyroidism and therefore should not be requested'. This does not hold true for neonates who are identified by newborn screening to have connatal hypothyroidism, i.e. thyrotrophin above 7 mU/l and T4 below 6 ug/dl, as defined...

BACKGROUND There are limited data about the influence of hypothyroidism and hyperthyroidism on the connective tissue component and smooth muscle cells of the thoracic aorta. The aim was to study the histological changes of the wall of the thoracic aorta in the hypothyroid and hyperthyroid rats. Morphometric measurements were also done. MATERIALS AND METHODS Thirty adult rats were used. They w...

Isolated adipocytes and soleus muscles prepared from mature rats, rendered hypothyroid by a low iodine diet and propylthiouracil, markedly resisted the ability of insulin to increase glucose utilization. In adipocytes, the sum of basal d-(1-(14)C)-glucose conversion to CO(2), glyceride-glycerol, and fatty acid was unaltered by hypothyroidism, although conversion to fatty acid was decreased. The...

MicroRNAs (miRNAs) are extensively involved in diverse biological processes. However, very little is known about the role of miRNAs in mediating the action of thyroid hormones (TH). Appropriate TH levels are known to be critically important for development, differentiation and maintenance of metabolic balance in mammals. We induced transient hypothyroidism in juvenile mice by short-term exposur...

Hypothyroid myopathy has so far been reported in long standing cases of hypothyroidism. We describe two adult patients with myopathy associated with acute transient hypothyroidism. Both presented with severe muscle aches and cramps, stiffness and spasms. Muscle enzymes were markedly elevated and electromyography in one patient showed myopathic features. Histological changes were absent in muscl...