The purpose of this research was to formulate and systemically evaluate in-vitro and in-vivo performances of mucoadhesive propranolol hydrochloride microspheres for its potential use in the treatment of hypertension, myocardial infraction and cardiac arrhythmias. Propranolol hydrochloride mucoadhesive microspheres, containing carbopol-934P as mucoadhesive polymer and ethyl cellulose as carrier ...

visit-to-visit variability (vvv) in blood pressure (bp) creates challenges to hypertension control and was independent associated with increased all-cause mortality in hypertensive patients. the major goal of the present study was to investigate the association of vvv in systolic (s)bp with progression of carotid atherosclerosis and en-dothelial dysfunction in on-treated hypertensive patients.o...

Background: With the development of technology, human beings are increasingly under the exposure of Radio Frequency Radiation (RFR) (due to wireless technologies, mobile phones, base stations etc). The aim was to investigate the possible effects of Radio Frequency Radiation (RFR) on blood, aorta and heart tissue in hypertensive and non-hypertensive rats with various parameters. Materials and Me...

It has been previously documented that the thermolysin digest of “Katsuobushi,” or dried bonito, a traditional Japanese food, potently inhibits the angiotensin I-converting enzyme (ACE). This hydrolyzate “Katsuobushi oligopeptide (KO)” has antihypertensive effects in hypertensive subjects at a dose of 3 g/day. In order to reduce the amount of KO required to produce an effect, we obtained a stro...

introduction: different vasoactive factors can modulate cardiovascular adaptation to hemorrhagic shock including nitric oxide (no). in this study we investigated the effect of  the no synthase inhibitor for treatment of  decompensated hemorrhagic shock in normotensive and hypertensive rats. methods: twenty‑four male wistar rats were divided into two groups: the normotensive and hypertensive gro...

agent oriented software engineering (aose) is an emerging field in computer science  and  proposes some systematic ideas for multi agent systems analysis, implementation and maintenance. despite the various methodologies introduced in the agent-oriented software engineering, the main challenges are defects in different aspects of methodologies. according to the defects resulted from weaknesses ...