Parkinson's disease has traditionally been viewed as a motor disorder caused by the loss of dopamine (DA) neurons. However, emotional and cognitive syndromes can precede the onset of the motor deficits and provide an opportunity for therapeutic intervention. Potassium channels have recently emerged as potential new targets in the treatment of Parkinson's disease. The selective blockade of small...

Midbrain dopamine (DA) modulates the activity of basal ganglia circuitry important for motor control in a variety of species. In songbirds, DA underlies motivational behavior including reproductive drive and is implicated as a gatekeeper for neural activity governing vocal variability. In the zebra finch, Taeniopygia guttata, DA levels increase in Area X, a song-dedicated subregion of the basal...

Introduction: This study examined the dosimetric effects based on the rotational setup error to correct patient setup errors occur during volumetric modulated arc radiotherapy (VMAT) for brain tumor patients. Material and Methods: This study included 1129 cases of cone beam computed tomography (CBCT) images obtained from 46 brain tumor patients, who experienced VMAT and used the 6DoF (degree o...

OBJECT The goal of this study was to investigate the ability of fetal dopaminergic neurons to improve complex sensorimotor behavior. METHODS The authors obtained ventral mesencephalic tissue from 14-day-old rat fetuses. The cells were exposed to glial cell line-derived neurotrophic factor (GDNF) prior to transplantation into rats with unilateral 6-hydroxydopamine lesions of the dopaminergic n...

Parkinson's disease (PD) is characterized by a myriad of symptoms, encompassing both motor disabilities and cognitive impairments. Recent research has shown that abscisic acid (ABA) phytohormone found in various brain regions several mammals exhibits neuroprotective properties. To investigate the effects ABA on disorders, mouse model PD was utilized. The administration 6-hydroxydopamine (6-OHDA...

In this article effects of friction stir welding (FSW) tool rotational and traverse speeds were studied on heat generation and temperature distribution in welding zone of AA1100 aluminum alloy and A441 AISI joint. Computational fluid dynamics method was used to simulate the process with commercial CFD Fluent 6.4 package. To enhance the accuracy of simulation in this Study, the welding line that...

We present multiphoton microendoscopy with a rotational probe and a 1 m fiber-based femtosecond laser. The rotational probe is based on a double-clad photonic crystal fiber, a gradient index lens, a microprism, and a rotational microelectronicmechanical system (MEMS) motor. The MEMS motor has a diameter of 2.2 mm and can provide 360° full-view rotation. The fiber laser provides ultrashort pulse...

Slowing or halting the progressive dopaminergic (DA) degeneration in Parkinson's disease (PD) would delay the onset and development of motor symptoms, prolong the efficacy of pharmacotherapies and decrease drug-induced side-effects. We tested the potential of two orally administered novel immunophilin ligands to protect against DA degeneration in two animal models of PD. First, in an MPTP (N-me...