Matrix metalloproteinases (MMPs) may have a role in the process of aseptic loosening. Doxycycline has been shown to inhibit MMPs. Our aim was to investigate the potential pharmacological effect of doxycycline on aseptic loosening. We used radiolabelled mouse calvariae cultured with human interface membrane cells from aseptically loosened hips. Bone resorption was confirmed in this model. The ef...

Cockett, F. B., and Maurice, B. A. (1963). British Medical_Journal, 1, 353. D'Abreu, A. L., Rob, C. G., and Vollmar, J. F. (1959). Langenbecks Archiv fur klinische Chirurgie, vereinigt mit Deustche Zeitschrift fiur Chirurgie, 290, 52. De Bakey, M. E., Crawford, E. S., Cooley, D. A., and Morris, G. C. (1958). Annals of Surgery, 148, 306. Doberneck, R. C., and Varco, R. L. (1968). Lancet, 88, 143...

BACKGROUND Reprogramming adult human somatic cells to create human induced pluripotent stem (hiPS) cell colonies involves a dramatic morphological and organizational transition. These colonies are morphologically indistinguishable from those of pluripotent human embryonic stem (hES) cells. G protein-coupled receptors (GPCRs) are required in diverse developmental processes, but their role in plu...

BACKGROUND Osteonecrosis of the femoral head can lead to destruction of the hip joint and disabling arthritis in young adults, if left untreated. Among the salvage procedures, core decompression combined with bone graft substitutes is a viable option for joint preservation. The purpose of this study was to review the outcomes of using synthetic bone graft substitute (calcium sulfate and calcium...

BACKGROUND We investigated the rate of conversion to total hip arthroplasty by twenty years and radiographic findings at a minimum of twenty years after rotational acetabular osteotomy. METHODS Between June 1986 and August 1991, we performed 172 rotational acetabular osteotomies in 168 patients with acetabular dysplasia. Of those, ninety-three hips (ninety-one patients), including twenty-thre...

We present the mid- to long-term results of the Chiari pelvic osteotomy for dysplastic hips. We followed 135 hips in 129 patients, with a mean age at the time of surgery of 24 years, for a mean of 16.2 years We used the anterior iliofemoral approach without trochanteric osteotomy in the initial 31 hips. Thereafter, we used transtrochanteric approaches in an attempt to ensure that the osteotomy ...

Abnormal morphology of the hip has been associated with primary osteoarthrosis. We evaluated the morphology of 464 consecutive hips contralateral to hips treated by THA. We excluded all hips with known diagnoses leading to secondary osteoarthritis and all hips with advanced arthrosis to eliminate the effect of arthritic remodeling on the morphologic measurements. Of the remaining 119 hips, 25 w...

We evaluated radiologic and clinical features affecting the outcome of hybrid metal-on-metal surface arthroplasty of the hip in 119 hips in patients 40 years and younger. Only the hips that had either failed or had minimum 2-year followup were reviewed. Ninety-four hips in 83 patients with a mean age of 34.2 years (range, 15-40 years) were reviewed. Seventy-one percent of the patients were male...

OBJECTIVE Develop and assess the psychometric properties of the Carer - Head Injury Participation Scale (C-HIPS) and its biggest factor the Carer - Head Injury Neurobehavioral Assessment Scale (C-HINAS). Furthermore, the aim was to examine the inter-informant reliability by comparing the self reports of individuals with traumatic brain injury (TBI) with the carer reports on the C-HIPS and the C...

The results of patients with rheumatoid arthritis who had revision hip arthroplasty have been studied infrequently. The purpose of this study was to review the authors' clinical and radiographic experiences and outcomes with revision hip arthroplasty. Revision total hip arthroplasties were done on 28 patients (30 hips). All hips had morselized bone grafting and four hips had bulk allografts for...