The Malarial parasite resides in the host RBC during its erythrocytic cycle. Plasmodium meets its entire nutritional requirement from RBC. It scavenges the hemoglobin of RBCs to meet its amino acid requirement. The host hemoglobin is made of different chains and it is dependent on age. Hemoglobin F (HbF), which has two-alpha and two gamma chain persists in children upto six years, and hemoglobi...

The maturity of organ functioning is a key to predicting neonatal prognosis, particularly in preterm babies, and laboratory tests have the potential for providing better information than external exams. This approach was examined utilizing the fetal protein, HGB F. While HGB F itself does not correlate well with current measures of maturity, HGB F/WT was found to correlate very strongly, in a l...

Liganded hemoglobin is a stronger acid than ligand-free hemoglobin. The kinetics of the transformation between these states was studied in the pH range 6.9 to 9.0 in 0.3 M NaCl with a pH indicator (phenol red or m-cresol purple) to follow the pH changes accompanying flash photolysis of human carbon monoxide hemoglobin. At least three distinct processes involving protons were detected kineticall...

The titration curves of the human hemoglobins AZ and F, the slow and fast components of horse hemoglobin, and bovine hemoglobin B have been analyzed, mainly to obtain information about the titration behavior of the histidines in these hemoglobins. The results were also compared with earlier data concerning human hemoglobin A and bovine hemoglobin A. In both hemoglobin As and F, 18 titratable hi...

Rabbit antibodies specific for the major tadpole and frog hemoglobin components of R. catesbeiana were used for the detection of the two hemoglobins inside single cells . The antisera, after fractionation by ammonium sulfate precipitation and diethylaminoethyl (DEAE)cellulose chromatography, were conjugated with fluorescein isothiocyanate for the antifrog hemoglobin serum and tetramethylrhodami...

INTRODUCTION Hemoglobin disorders are classified into three main groups: structural variants, thalassemias (thal) and hereditary persistence of fetal hemoglobin (HPFH). OBJECTIVE. This study describes the types and frequencies of hemoglobinopathies from four states of the Pacific coast of Mexico (Jalisco, Colima, Nayarit and Michoacan). MATERIAL AND METHODS. We studied 1513 Mexican individuals ...

To try to further define the mechanisms that increase the levels of hemoglobin F (HbF) in the blood of patients with severe forms of beta thalassemia, we have studied two comparable populations of hemoglobin E (HbE)/beta thalassemics, one regularly transfused and one receiving only occasional blood transfusions. Regular transfusion was associated with a significant decrease in soluble transferr...

We report a new type of deletion of the fi globin gene cluster in the Italian population that confers a phenotype of hereditary persistence of fetal hemoglobin (HPFH) to the carriers. This deletion begins -5 kilobases (kb) 5’ to the #{246} globin gene and ends -30 kb 3’ to the fi globin gene. in close proximity to the 3’ end of an Indian HPFH. In all four previously described HPFH. a repetitive...

recobrase su firmeza. Como el tratamiento no tenía fecha de finalización Toda se vio obligada a regresar a Navarra, puesto que era la reina regente tras la muerte de su marido, dejando a su nieto en manos de los médicos árabes. El resultado de la dieta y el ejercicio físico no se hizo esperar, después de someterse durante 40 largos días a esta estricta y nociva dieta consiguió rebajar su peso a...

Hemoglobin, which widely exists in all vertebrates and in some invertebrates, is possibly a precursor of antimicrobial peptides (AMPs). However, AMPs in the hemoglobin of invertebrates have been rarely investigated. This study is the first to report the full-length cDNA, prokaryotic expression, and antimicrobial activity of UuHb-F-I from Urechis unicinctus. The full-length cDNA sequence of UuHb...