نتایج جستجو برای: gabaergic system

تعداد نتایج: 2239045  

2013
Celine Fuchs Karine Abitbol Jemima J Burden Audrey Mercer Laura Brown Jonathan Iball F Anne Stephenson Alex M Thomson Jasmina N Jovanovic

The mechanisms that underlie the selection of an inhibitory GABAergic axon's postsynaptic targets and the formation of the first contacts are currently unknown. To determine whether expression of GABAA receptors (GABAA Rs) themselves--the essential functional postsynaptic components of GABAergic synapses--can be sufficient to initiate formation of synaptic contacts, a novel co-culture system wa...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Yan-Chun Li Christoph Kellendonk Eleanor H Simpson Eric R Kandel Wen-Jun Gao

Two distinct defects are thought to be important for the pathophysiology of schizophrenia. One is an increase of D2 receptors (D2Rs) in the striatum and another is a decrease in the GABAergic function in the prefrontal cortex (PFC). Whether these two defects are functionally linked is not known. We previously reported that selective overexpression of D2Rs in the striatum of the mouse causes beh...

Journal: :Journal of neurophysiology 2011
Tao Liu Tsugumi Fujita Eiichi Kumamoto

GABAergic and glycinergic inhibitory synaptic transmissions in substantia gelatinosa (SG; lamina II of Rexed) neurons of the spinal dorsal horn play an important role in regulating nociceptive transmission from the periphery. It has not yet been well known whether each of the inhibitory transmissions plays a distinct role in the regulation. We report an involvement of neurotransmitters in GABAe...

2016
Xin Jin Shanshan Li Brian Bondy Weiwei Zhong Max F. Oginsky Yang Wu Christopher M. Johnson Shuang Zhang Ningren Cui Chun Jiang Benjamin Arenkiel

The locus coeruleus (LC)-norepinephrine (NE) system in the brainstem plays a critical role in a variety of behaviors is an important target of pharmacological intervention to several neurological disorders. Although GABA is the major inhibitory neurotransmitter of LC neurons, the modulation of LC neuronal firing activity by local GABAergic interneurons remains poorly understood with respect to ...

Journal: :avicenna journal of phytomedicine 0
fatemeh forouzanfar department of pharmacology, faculty of medicine, mashhad university of medical sciences, mashhad, iran ahmad ghorbani pharmacological research center of medicinal plants, school of medicine, mashhad university of medical sciences, mashhad, iran hasan rakhshandeh department of pharmacology, faculty of medicine, mashhad university of medical sciences, mashhad, iran mahmoud hosseini neurocognitive research center, faculty of medicine, mashhad university of medical sciences, mashhad, iran

objective: insomnia is accompanied by several health complications and the currently used soporific drugs can induce several side effects such as psychomotor impairment, amnesia, and tolerance. the present study was planned to investigate the sleep prolonging effect of pinus eldarica. materials and methods: hydroalcoholic extract (hae) of p. eldarica, its water fraction (wf), ethyl acetate frac...

Journal: :Journal of neurophysiology 2011
Christian Schultheis Martin Brauner Jana F Liewald Alexander Gottschalk

In the nervous system, a perfect balance of excitation and inhibition is required, for example, to enable coordinated locomotion. In Caenorhabditis elegans, cholinergic and GABAergic motor neurons (MNs) effect waves of contralateral muscle contraction and relaxation. Cholinergic MNs innervate muscle as well as GABAergic MNs, projecting to the opposite side of the body, at dyadic synapses. Only ...

2014
Casie Lindsly Carlos Gonzalez-Islas Peter Wenner

Synaptic scaling represents a process whereby the distribution of a cell's synaptic strengths are altered by a multiplicative scaling factor. Scaling is thought to be a compensatory response that homeostatically controls spiking activity levels in the cell or network. Previously, we observed GABAergic synaptic scaling in embryonic spinal motoneurons following in vivo blockade of either spiking ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
Anne-Emilie Allain Pierre Meyrand Pascal Branchereau

During the development of the nervous system, the acquisition of the GABA neurotransmitter phenotype is crucial for neural networks operation. Although both intrinsic and extrinsic signals such as transcription factors and growth factors have been demonstrated to govern the acquisition of GABA, few data are available concerning the effects of modulatory transmitters expressed by axons that prog...

Journal: :Developmental neuroscience 2011
Jose Luis Olmos-Serrano Joshua G Corbin Mark P Burns

Hyperactivity, hypersensitivity to auditory stimuli, and exaggerated fear are common behavioral abnormalities observed in individuals with fragile X syndrome (FXS), a neurodevelopmental disorder that is the most common genetic cause of autism. Evidence from studies of the Fmr1 knockout (KO) mouse model of FXS supports the notion that impaired GABAergic transmission in different brain regions su...

2013
Daniel S. Razik David J. Hawellek Bernd Antkowiak Harald Hentschke

In the central nervous system, GABA transporters (GATs) very efficiently clear synaptically released GABA from the extracellular space, and thus exert a tight control on GABAergic inhibition. In neocortex, GABAergic inhibition is heavily recruited during recurrent phases of spontaneous action potential activity which alternate with neuronally quiet periods. Therefore, such activity should be qu...

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