OBJECTIVE To investigate the effect of altering internal Na and cell Ca load on the voltage-dependence of the intracellular Ca transient. METHODS Ventricular myocytes were isolated enzymatically from the guinea-pig heart. They were patch clamped and dialysed internally with pipette solutions which contained either 0 or 10 or 20 mM Na. Intracellular Ca was monitored with Indo-1 and experiments...

L-NAME (LN) induces hypertension by blocking nitric oxide (NO) synthesis. It produces vascular hyperreactivity to phenylephrine (PHE) associated with a reduced vascular Na+, K+-ATPase activity. The aim of this work was to investigate whether products of the cyclooxygenase pathway are involved in alterations of vascular reactivity and Na+-pump activity in the tail artery from LN-induced hyperten...

INTRODUCTION The Indo-Guyanese population is the largest immigrant minority population in Schenectady, New York. A clinic-based study in Schenectady and surveillance reports from Guyana found high diabetes prevalence and mortality among Guyanese of Indian descent. No community-based study has focused on diabetes among Indo-Guyanese immigrants in the United States. We sought information on the p...

Over the past three decades, coral reefs worldwide have experienced significant losses in living coral cover and changes in the structure and function of these communities. Infectious diseases have been recognized as a prominent cause of mortality in scleractinian corals in the western Atlantic since the 1980’s, but until recently there were few reports of coral disease from the Indo-Pacific re...

The Indo-Aryan language family currently occupies a significant region of the Indian subcontinent, its member languages being spoken in the bulk of North India, as well as in Pakistan, Bangladesh, Nepal, Sri Lanka, and the Maldives. The historical depth of the textual record and the geographical breadth of the Indo-Aryan linguistic area, the diversity of its languages (226 in all), and its many...

Because the regulation of vascular function involves complex mutual interactions between nitric oxide (NO) synthase (NOS) and cyclooxygenase (COX) products, we examined the contribution of NO and prostanoids derived from the COX pathway in modulating aortic baroreceptor resetting during an acute (30 min) increase in arterial pressure in anesthetized rats. Increase in pressure was induced either...