Alport syndrome is an inherited disease characterized by progressive renal failure, hearing loss, and ocular abnormalities. Mutations in the COL4A5 (X-linked), or COL4A3 and COL4A4 (autosomal recessive) genes result in absenceof the collagen IVa3a4a5network fromthebasementmembranesof the cornea, lens capsule, and retinaand are associatedwith corneal opacities, anterior lenticonus, fleck retinop...

Article history: Received 22 October 2011 Received in revised from 14 February 2013 Accepted 22 March 2013 Available online 2 April 2013

Progress in the reconstruction of Quaternary climate dynamics in the Northwest Pacific: A new modern analogue reference dataset and its application to the 430-kyr pollen record from Lake Biwa Pavel E. Tarasov ⁎, Takeshi Nakagawa , Dieter Demske , Hermann Österle , Yaeko Igarashi , Junko Kitagawa , Lyudmila Mokhova , Valentina Bazarova , Masaaki Okuda , Katsuya Gotanda , Norio Miyoshi , Toshiyuk...

Effects of Process Conditions on Properties of Electroplated Ni Thin Films for Microsystem Applications J. K. Luo, M. Pritschow, A. J. Flewitt, S. M. Spearing,* N. A. Fleck, and W. I. Milne Department of Engineering, University of Cambridge, Cambridge CB3 0FA, United Kingdom Institute for Microelectronics Stuttgart, 70569 Stuttgart, Germany School of Engineering Science, University of Southampt...

This year's World Health Day is on food safety. The mass use of antibiotics in animal husbandry is contaminating the food supply with resistant bacteria, causing difficult-to-treat infections while reducing the power of antibiotics to cure human infections. Antoine Andremont talks to Fiona Fleck.

The complete genome of citrus leprosis virus nuclear type (CiLV-N) was identified by small RNA sequencing utilizing leprosis-affected citrus samples collected from the state of Querétaro, Mexico. The nucleotide identity and phylogenetic analysis indicate that CiLV-N is very closely related to orchid fleck virus, which typically infects Cymbidium species.

purpose: to report multiple astrocytic hamartomas in a patient with tuberous sclerosis (ts). patient and findings: a 16-year-old girl with ts without any ocular complaint was referred for ophthalmologic examination. she had papular rash on her face and other skin lesions elsewhere in the body which were specific for ts. multiple well-circumscribed elevated lesions characteristic of astrocytic h...

OBJECTIVE To study the longitudinal changes in autofluorescence in Stargardt disease to reveal aspects of disease progression not previously evident. Changes in autofluorescence reflect changing fluorophore compositions of lipofuscin and melanin in retinal pigment epithelial cells, which has been hypothesized to contribute to Stargardt disease pathogenesis. METHODS We examined the temporospat...

N A Fleck, R M McMeeking, T Kraus 1 Corresponding author, Cambridge University Engineering Dept., Trumpington St., Cambridge, CB2 1PZ, UK 2 INM – Leibniz Institute for New Materials, Campus D2 2, Saarbrücken, Germany 3 Mechanical Engineering and Materials Departments, University of California, Santa Barbara, CA 93106, USA 4 School of Engineering, University of Aberdeen, King’s College, Aberdeen...

As countries gear up for a major round of international climate talks next year in Paris, the growing problem of air pollution is fast becoming a vital part of the climate change and health debate. Fiona Fleck talks to Marit Viktoria Pettersen.