1. Carnitine acetyltransferase is very rapidly inhibited in the presence of bromoacetyl-(-)-carnitine plus CoA or of bromoacetyl-CoA plus (-)-carnitine. 2. Under appropriate conditions, the enzyme may be titrated with either bromoacetyl substrate analogue; in each case about lmole of inhibitor is required to inactivate completely 1 mole of enzyme of molecular weight 58 000 + 3000. 3. Inhibition...

Amritotharanam Kashyam, a specific Ayurvedic drug, was the focus of current inquiry to evaluate its efficacy. For liver and digestive-related issues, this medication is suggested. This obtained from standard vendor in Chennai (India), GC-MS analysis carried out according procedure. A few critical biomolecules include benzoic acid, hexadecanoic 6,9-octadecadienoic 9-octadecenoic methyl ester (E)...

We have previously observed that cholesterol-fed dogs with plasma cholesterol levels of 350 to 750 mg/dl failed to develop atherosclerosis (hyporesponders), whereas cholesterol-fed dogs with cholesterol levels greater than 750 mg/dl developed markedly accelerated atherosclerosis (hyperresponders). Two striking features of the hypercholesterolemia of the hyperresponders were the occurrence of ch...

Nonribosomal peptide synthetases (NRPSs) catalyze the biosynthesis of many biologically active peptides and typically are modular, with each extension module minimally consisting of a condensation, an adenylation, and a peptidyl carrier protein domain responsible for incorporation of an amino acid into the growing peptide chain. C-1027 is a chromoprotein antitumor antibiotic whose enediyne chro...

We have previously observed that cholesterol-fed dogs with plasma cholesterol levels of 350 to 750 mg/dl failed to develop atherosclerosis (hyporesponders), whereas cholesterol-fed dogs with cholesterol levels greater than 750 mg/dl developed markedly accelerated atherosclerosis (hyperresponders). Two striking features of the hypercholesterolemia of the hyperresponders were the occurrence of ch...

We examined the roles of phospholipase A2 (PLA2) in oxidized LDL (oxLDL)-induced cholesteryl ester formation in macrophages. In [3H]oleic acid-labeled RAW264.7 cells and mouse peritoneal macrophages, oxLDL induced [3H]cholesteryl oleate formation with an increase in free [3H]oleic acid and a decrease in [3H]phosphatidylcholine. The changes in these lipids were suppressed by methyl arachidonyl f...

In the production of structures made from reinforced cyanate ester resins, nearly complete cyclotrimerization of the resin with concomitant macromolecular network formation must be achieved in order to ensure adequate mechanical performance and durability of the structures. In the course of developing a wide variety of new cyanate ester resins, as well as in studies of cocured blends, it has be...

A new mechanism is described for the cellular esterification of cholesterol derived from extra-cellular lipoproteins. Incubation of monolayers of cultured fibroblasts from normal human subjects with low density lipoproteins led to a 30- to 40-fold increase in the rate of incorporation of either [(14)C]acetate or [(14)C]oleate into the fatty acid fraction of cholesteryl [(14)C]esters. This stimu...

Efficient total syntheses of fluvibactin and vibriobactin have been achieved via molybdenum(VI) oxide-catalyzed dehydrative cyclization, Sb(OEt)(3)-catalyzed ester-amide transformation, and WSCI and HOAt-promoted dehydrative amide formation.

Brucine diol (BD) catalyzed asymmetric Morita–Baylis–Hillman (MBH) reaction is observed for the first time. N-oxide (BNO) was found to not have an effective chiral catalyst. Faster rate obtained using unsaturated ester or aromatic aldehydes in presence of BNO. 4-Nitrobenzaldehyde and α,β-unsaturated ketone/ester were converted MBH adduct moderate yields (up 74%) with 70% ee value by this cataly...