Aim: To identify the Clostridium perfringens toxin genotypes prevailing in enterotoxemia suspected sheep flocks in Andhra Pradesh by using multiplex PCR. Materials and Methods: Intestinal scrapings were collected from lambs below three months of age from flocks with similar management from different Districts of Andhra Pradesh, in India. A total of 208 samples were collected with 140 from enter...

ε-Toxin is a pore forming toxin produced by Clostridium perfringens types B and D. It is synthesized as a less active prototoxin form that becomes fully active upon proteolytic activation. The toxin produces highly lethal enterotoxaemia in ruminants, has the ability to cross the blood-brain barrier (BBB) and specifically binds to myelinated fibers. We discovered that the toxin induced a release...

The study was designed to determine the hematological and biochemical changes in sheep following the experimental Clostridium perfringens type D infection. Mean leukocyte count was significantly higher (p < 0.05) between control and infected groups at 10 hours (11.2±0.3 vs 19.7±3.5), 20 hours (10.6±0.3 vs 16.9±0.2) and then started to decrease in infected group. A statistically significant incr...