نتایج جستجو برای: emperipolesis
تعداد نتایج: 125 فیلتر نتایج به سال:
Serglycin (SG), the hematopoietic cell secretory granule proteoglycan, is crucial for storage of specific secretory proteins in mast cells, neutrophils, and cytotoxic T lymphocytes. We addressed the role of SG in platelets using SG-/- mice. Wild-type (WT) but not SG-/- platelets contained chondroitin sulfate proteoglycans. Electron microscopy revealed normal alpha-granule structure in SG-/- pla...
Hemal lymph nodes are characterized by a high content of blood cells most of them in different stages of erythrophagocytosis. These peculiar structures are not well understood up to now regarding their functional morphology. Above all, their biological relevance, especially to the phenomenon of disintegration of one's own blood cells, has eluded conclusive explanation so far. In the present stu...
Splenomegaly is a major manifestation of primary myelofibrosis (PMF) contributing to clinical symptoms and hematologic abnormalities. The spleen from PMF patients contains increased numbers of hematopoietic stem cells (HSC) and megakaryocytes (MK). These MK express high levels of P-selectin (P-sel) that, by triggering neutrophil emperipolesis, may cause TGF-β release and disease progression. Th...
Rosai-Dorfman disease (RDD) is a rare, benign histiocyte disorder originally described by Rosai and Dorfman in 1969 as sinus histiocytosis with massive lymphadenopathy. It most typically presents as massive, painless cervical lymphadenopathy, and it is most often found in adolescents and young adults. Extranodal involvement is a common feature of RDD and may occur in more than 40% of patients. ...
Cutaneous Rosai-Dorfman disease (CRDD) is a rare proliferative disorder of histiocytes with unknown etiology, broadly different from systemic Rosai-Dorfman disease. We present the largest series of CRDD, describing the clinical manifestation, histopathology, immunohistochemistry, and follow-up course of 25 cases in China. Clinically, 39 skin lesions in 25 patients were divided into 3 main types...
An extensive and detailed differential presentation of light and electron microscopic aspects of the various types of hepatitis B, non-A, non-B, and autoimmune hepatitis which is of equal practical and diagnostic importance for both clinicians and pathologists, remains to be written. Nowadays, hepatitis A, occurring only as an acute disease, can be diagnosed reliably by means of serological tes...
Reprint requests to: Dr. Shu-Hang Ng Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou and College of Medicine, Chang Gung University. No. 5, Fu Hsing Road, Gueishan , Taoyuan 333, Taiwan, R.O.C. Rosa i Dor fman d i sease ( R DD) i s a rare , benign pseudolymphatous condition, predominantly involving lymph nodes. Extranodal RDD presenting as metachronous nasal...
to extend our knowledge about such interactions substantially beyond that afforded by other presently used methods. In essence, the method uses primary explants of human cancers in autologous and short-term tissue culture systems and permits several useful measurements of distinctive types of lymphocyte activities. In particular, the presence or absence of different types of lymphocyte activiti...
Drug induced liver injury (DILI) is a disease caused by xenobiotics (drugs, herbal or diet products) and diagnosed by exclusion of other causes. Some drugs that cause DILI can also cause drug induced autoimmune hepatitis (DI-AIH) by triggering the immune response against liver proteins (1, 2). A 24-yr old male patient in 2015, was admitted to Turkiye Yuksek Ihtisas Hospital, gastroenterology cl...
Dapsone as a potential treatment for cutaneous Rosai-Dorfman disease with neutrophilic predominance.
A 31-year-old Taiwanese woman, who from her medical history was generally well, presented with 1 slowly enlarging elevated plaque on the posterior aspect of her right shoulder. This had first been detected 3 months before the visit to our clinic. The lesion had originated as a small, tender, erythematous papule and had since grown into a large confluent plaque with satellite papules. She claime...
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