Ranks. San Francisco, McGraw-Hill, 1975, p 125 15. Lehman EL: Nonparametrics: Statistical Methods Based on Ranks. San Francisco, McGraw-Hill, 1975, p 316 16. Gibson DG, Prewitt TA, Brown DJ: Analysis of left ventricular wall movement during isovolumic relaxation and its relation to coronary artery disease. Br Heart J 38: 1010, 1976 17. Streeter DD Jr, Hanna WT: Engineering mechanics for success...

Retinoic acid (RA) induces cell cycle arrest and differentiation of human neuroblastoma (NB) cells. Typically, NB cells differentiate along the neuronal lineage, but quiescent, "flat" cell types frequently have been described after treatment with differentiating agents. Two indistinguishable subclones of the cell line SK-N-SH, SK-N-SH-N (SH-N) and SK-N-SH-F (SH-F), display dramatically differen...

OBJECTIVE Subclinical hypercortisolism (SH) is suggested to exert a deleterious effect on bone. This effect and the role of gonadal status in male subjects are not fully elucidated. We evaluated bone mineral density (BMD) and prevalence of vertebral fractures in eugonadal male subjects with adrenal incidentalomas (AI) and without SH. DESIGN This 12-month observational multicentre study was pe...

In recent years, the condition of subclinical hypercortisolism (SH) has become a topic of growing interest. This is due to the fact that SH prevalence is not negligible (0.8-2% in the general population) and that, although asymptomatic, this subtle cortisol excess is not harmless, being associated with an increased risk of complications, in particular of osteoporosis and fragility fractures. As...

Aim: Mast cells are versatile innate immune cells and are reported to promote vascular inflammation and neointimal lesion formation, thereby contributing to the development of vascular stenosis and atherosclerosis. However, it is not clear whether mast cells also regulate vascular matrix remodelling in established neointima. This study addressed the hypothesis that perivascular mast cells regul...

The spatio-temporal expression of Shaker (Sh) potassium channels (Kch) in the developing and adult nervous system of Drosophila has been studied at the molecular and histological level using specific antisera. Sh Kch are distributed in most regions of the nervous system, but their expression is restricted to only certain populations of cells. Sh Kch have been found in the following three locati...

common lupus. BMJ 1888; 1:58–63 3 Su WP, Perniciaro C, Rogers RS III, et al. Chilblain lupus erythematosus (lupus pernio): clinical review of the Mayo Clinic experience and proposal of diagnostic criteria. Cutis 1994; 54:395–399 4 Hedrich CM, Fiebig B, Hauck FH, et al. Chilblain lupus erythematosus: a review of literature. Clin Rheumatol 2008; 27:1341 5 Richez C, Dumoulin C, Schaeverbeke T. Inf...

Shikonin has anticancer activity, but it has not yet been applied into clinical use. In the present study, shikonin was prepared using liposomes. We aimed to examine several aspects of sh-L (shikonin-containing liposomes): preparation, angiogenic suppression and cellular uptake through self-fluorescence. Sh-L were prepared using soybean phospholipid and cholesterol to form the membrane and shik...

This paper continues the study of the relationship between electron density and carcinogenic activity for compounds related to p-dimethylaminoazobenzene (Cancer Res., 29: 1341-1344, 1969) and reports on the seven p-dimethylaminophenylazoquinolines. A relationship was found between carcinogenic activity and the pKfl of the amino nitrogen in these compounds, and in this new series a relationship ...