Genital infection by high risk Human Papillomavirus (HR-HPV), although recognized as the main etio-pathogenetic factor of cervical cancer, is not per se sufficient to induce tumour development. Oxidative stress (OS) represents an interesting and under-explored candidate as a promoting factor in HPV-initiated carcinogenesis. To gain insight into the role of OS in cervical cancer, HPV-16 positive...

Many uncertainties surround the definition, frequency, and significance of dysplastic nevi in children. Consequently the management of dysplastic nevi in the pediatric population has been largely derived from the studies of adults. Biopsies are usually performed on this young age group because of lesion change or abnormal appearance. One might therefore assume that the frequency of histological...

This study addresses the results of the experimental measurements for the contact surface areas and contact pressure distributions of a dysplastic hip joint. The hip joint consists of pelvis, proximal femur and artificial cartilages for both acetabulum and femoral head. The dysplastic hip joint is modeled in three dimensional (3D) form using the computerized tomography (CT) images obtained in v...

The aim of this study was to determine if dysplastic endocervical cells (EC) posses a neoplastic potential as precursor lesions to adenocarcinoma in situ (AIS). The malignant potential was determined by assessing the ploidy status and proliferative activity by flow cytometry and c-myc expression by immunohistochemistry. The studied parameters were assessed separately in morphologically normal, ...

Drug abuse has been claimed to cause the loss of neurons and reduction of volume in both the adult and developing brain. This study examined cortex volumes in cerebrum and cerebellum of male rats that were dependent on morphine using unbiased stereological counting methods and systematic random sampling technique. Our goal was to test whether short time exposure to morphine can affect the corte...

BACKGROUND AND PURPOSE The appearance of acetabular version differs between the supine and weight bearing positions in developmental dysplasia of the hip. Weight bearing radiographic evaluation has been recommended to ensure the best coherence between symptoms, functional appearance, and hip deformities. Previous prevalence estimates of acetabular retroversion in dysplastic hips have been estab...

　Introduction: Previous studies have suggested that the cerebellum is a primary site of motor learning. The cerebellar cortex has a particular glial architecture with large astroglial cells. In addition, more recent works have revealed that astrocytes play a more active role in neuronal activity. The aim of this study was to evaluate the number of astrocytes in the molecular layer of rat's cere...

Antidepressant activity of crocin, saffron main component, has been established before. Based on previous study, it is suggested that elevation in the levels of BDNF (brain-derived neurotrophic factor), CREB (cAMP response element binding) and VGF neuropeptide could be considered as one probable molecular mechanisms involved in antidepressant activity of long term crocin administration in the r...