Abstract We investigate the transport of interacting active run-and-tumble particles moving under an external drift force through a periodic array obstacles for increasing drive amplitudes. For high activity where system forms motility-induced phase-separated state, there are several distinct dynamic phases including low pinned cluster phase, intermediate uniform fluid, and higher stripe crysta...

OBJECTIVES The goal of this report is to present an individual patient's survival estimation curve using the each institution's survival data after Cox proportional hazard analysis. METHODS The program was developed in three parts: input of basic data from Cox proportional hazard analysis, input of individual patient's covariates, and presentation of individual patient's survival curve. In th...

Background It is not uncommon for clinical trials to present results on survival time as Kaplan-Meier survival curves that cross, indicating non-proportional hazards. A recent example was given in a pivotal trial in advanced nonsmall cell lung cancer (The ‘IPASS study’ [1]). Trials such as these present a hazard ratio and log-rank test for treatment comparison as this is their planned primary a...

Analyzing events over time is often complicated by incomplete, or censored, observations. Special non-parametric statistical methods were developed to overcome difficulties in summarizing and comparing censored data. Life-table (actuarial) method and Kaplan-Meier method are described with an explanation of survival curves. For the didactic purpose authors prepared a workbook based on most widel...

In the present study, we investigated the potential of N-BNP (N-terminal B-type natriuretic peptide) as a prognostic marker for risk of CV (cardiovascular) events, overall mortality and progression to ESRD (end-stage renal disease) in a cohort of 83 pre-dialysis CKD (chronic kidney disease) patients without clinical evidence of heart failure. During the study, ten patients reached the combined ...

• Simplified building model for seismic assessment using dynamic analyses. Model suitable non-shear-type buildings as it accounts beams flexibility. Torsional behaviour of irregular accurately captured. Remarkable reduction computational time. Validation on a 3D reinforced concrete moment resisting frame building. Seismic safety assessments at the large-scale are paramount importance densely ur...

Recent studies of flood risk at New York Harbor (NYH) have shown disparate results for the 100 year storm tide, providing an uncertain foundation for the flood mitigation response after Hurricane Sandy. Here we present a flood hazard assessment that improves confidence in our understanding of the region’s present-day potential for flooding, by separately including the contribution of tropical c...

In the framework of the European SCenarios for tsunami Hazard-induced Emergencies MAnagement (SCHEMA) project (www.schemaproject.org), we empirically developed new tsunami damage functions to be used for quantifying the potential tsunami damage to buildings along European-Mediterranean coasts. Since no sufficient post-tsunami observations exist in the Mediterranean areas, we based our work on d...

Human subjects decide when to sink a xed cost C to seize an irreversible investment opportunity whose value V is governed by Brownian motion. The optimal policy is to invest when V rst crosses a threshold V ∗ = (1+w∗)C, where the wait option premiumw∗ depends on drift, volatility, and expiration hazard parameters. Subjects in the Low w∗ treatment on average invest at values quite close to opt...