Introduction Mendelian susceptibility to mycobacterial disease (MSMD) is a rare form of primary immunodeficiencies characterized by predisposition for poorly virulent infection agents, primarily non-tuberculous mycobacteria and Salmonella. It has been shown that molecular basis of these diseases is mutations in at least 7 genes in the IL12-dependent IFN-g axis including IFNGR1, IFNGR2, IL-12/IL...

In response to systemic infection, mice usually present specific behaviors such as reduced activity and feeding, ruffled fur, hunched position, ataxia and tremor. We aimed to compare tissue bioluminescence, tissue cultures and clinical scores of BALB/c mice as potentially complementary outcome measures of Salmonella disease progression In Balb/c mice. The clinical status of the mice was assesse...

A range of different care providers with varying levels of expertise and experience, including primary care staff, general clinicians, and paediatricians, may be involved in managing children with tuberculosis (TB). Clarifying the roles and responsibilities of health care staff for the diagnosis, treatment and prevention of TB in children is important. Roles and responsibilities depend on the r...

BCG (Calmette-Gu6rin bacillus) is presumed to protect against tuberculosis by virtue of the specific immune response it provokes in the vaccinated subject, but the measurement of this response is beset with technicM problems. First, the tubercle bacillus, against which specific resistance must ultimately be measured, is a poor indicator of the resistance generated in response to immunization. N...

Soft tissue and superficial venous infections are uncommon extraintestinal manifestations of non-typhoidal Salmonella (NTS) infections. In contrast to affected adults, who usually show immunological impairment, the majority of children with extraintestinal NTS infections have no predisposing risk factors. Here, we report a previously healthy infant who developed hand abscess, phlebitis, bactere...

We present the case of a 28 year old lady with refractory Crohn's Disease treated with infliximab throughout her pregnancy. Her baby was born healthy and received a Bacillus Calmette-Guérin (BCG) vaccine aged 3 months. Soon after this the infant became unwell and died aged 4.5 months. At post-mortem the cause of death was attributed to an unusual complication of the BCG vaccine, known as dissem...

salmonella is a gram-negative, non-spore forming facultative anaerobic, motile bacilli. in developing countries, non-typhoidal salmonella (nts) accounts for the steadily increase in the proportion of human infections in recent decades. the clinical presentations of non-typhoidal salmonella infection are protean, including gastroenteritis (the most common one), bacteremia, septic arthritis, oste...