Oral Absorption and Disposition Kinetics of Lidocaine Hydrochloride in Dogs. R. N. BOYES, H. J. ADAMS AND B. R. DUCE 1 Maternal and Fetal Distribution of H3-Dihydromorphine in the Tolerant and Nontolerant Rat. S. Y. YEH AND L. A. WOODS 9 Retention of Inhaled Acetaldehyde in Man. JOHN L. EGLE, JR 14 Efflux of Chiorpromazine and Trifluoperazine from the Rat Brain. P. F. SPANO, N. H. NEFF, E. MACK...

This paper examines some cognitive biases of Vietnamese stock investors by analyzing trading records for 1,201 accounts at a brokerage firm. These investors tend to make poor trading decisions by selling good stocks and buying bad stocks. They demonstrate a significant reference to holding the losing stocks and selling the wining stocks which is known as the disposition effect. It provokes many...

Chronopharmacokinetics of rifampicin was studied in four healthy adult male human volunteers after drug (2.0 g) ingestion at 6.00, 12.00, 18.00 and 24.00 hr. The absorption rate constant was found to be lower and the time to reach peak concentration was longer after drug administration at 24.00 hr than at other dosing times. A second peak was observed in all individual volunteers between 6-12 h...

Oral Absorption and Disposition Kinetics of Lidocaine Hydrochloride in Dogs. R. N. BOYES, H. J. ADAMS AND B. R. DUCE 1 Maternal and Fetal Distribution of H3-Dihydromorphine in the Tolerant and Nontolerant Rat. S. Y. YEH AND L. A. WOODS 9 Retention of Inhaled Acetaldehyde in Man. JOHN L. EGLE, JR 14 Efflux of Chiorpromazine and Trifluoperazine from the Rat Brain. P. F. SPANO, N. H. NEFF, E. MACK...

The effect of ethyl alcohol ingestion on tetracycline kinetics was studied in 9 healthy male volunteers. They received, on two separate occasions, 500 mg of tetracycline tablets given with water or with an alcoholic beverage. The antibiotic was assayed in plasma, using a HPLC method. Absorption and disposition parameters were calculated according to classical pharmacokinetic techniques for one ...

Abstract Background Although heart failure (HF) is one of the most common conditions affecting heart, little attention has been placed on role arteries in contributing to progression this disease. Purpose We sought determine hemodynamic change HF patients subdivided according left ventricular ejection fraction. The major goal was establish active compensatory Methods Using sphygmography, we sys...

The ocular disposition and toxicity of GEM132, a mixed backbone phosphorothioate oligonucleotide developed for the treatment of cytomegalovirus-induced retinitis, were studied in rabbits for 6 months following single intravitreal injection of 5, 20, or 100 microgram/eye (toxicity) and 3.7, 15.7, or 78.5 microgram/eye (disposition). Intraocular pressure, electroretinograms, and ophthalmoscopy we...

With this fluorometric method for measuring indocyanine green (ICG) in biological fluids, the limit of detection is an order of magnitude lower than for the traditional spectrophotometric procedure. The excitation and emission maxima are 780 and 810 nm, respectively. Agreement was excellent (r = 0.998) between direct results by this method and those by a liquid-chromatographic procedure with sp...