Lifespan of laboratory animals can be increased by genetic, pharmacological, and dietary interventions. Increased expression of genes involved in xenobiotic metabolism, together with resistance to xenobiotics, are frequent correlates of lifespan extension in the nematode worm Caenorhabditis elegans, the fruit fly Drosophila, and mice. The Green Theory of Aging suggests that this association is ...

BACKGROUND & OBJECTIVES Development of insecticide resistance in malaria vectors has been a major problem for achieving effective vector control. Due to limited availability of insecticides, the only option is management of resistance by judiciously using the insecticides and rotating them to maintain their effectiveness. This study was carried out in a malaria endemic area of Sundergarh distri...

BACKGROUND Anopheles culicifacies is a main malaria vector in southeastern part of Iran, bordring Afghanistan and Pakistan. So far, resistance to DDT, dieldrin, malathion and partial tolerance to pyrethroids has been reported in An. stephensi, but nothing confirmed on resistance status of An. culicifacies in Iran. METHODS In current study, along with WHO routine susceptibility test with DDT (...

Malaria control is increasingly recognised as playing a key role in poverty reduction in high burdened countries. The programme for malaria eradication based on vector control using very large quantities of DDT started in 1949 in the country and resulted in a dramatic reduction in malaria incidence. Vector population recovery, mainly due to resistance to DDT in Anopheles populations as well as ...

Introduction The publication of Rachel Carson’s Silent Spring1 in 1962 brought in an increased awareness on the effects of chemicals in the environment and that human health is inextricably linked to the health of the environment. Since then there has been growing scientific concern, public debate and media attention over the possible effects in humans and wildlife that may result from exposure...

Background Malaria vector control efforts have taken malaria related cases down to appreciable number per annum after large scale of intervention tools. Insecticides-based tools remain the major control option for malaria vectors in Kenya and, therefore, the potential of such programs to be compromised by the reported insecticide resistance is of major concern. The objective of this study was t...

susceptibility levels of a lab strain of an. stephensi to who standard papers of ddt 4%, dieldrin 0.4%, malathion 5%, permethrin 0.25%, lambdacyhalothrin 0.1%, cyfluthrin 0.1% and deltamethrin 0.025% were determined in our laboratory in 1999. results showed that at the diagnostic dose of insecticides this species exhibited resistance to ddt and dieldrin with mortality rate of 54±2.5% and 30±2.5...

To the Editor: The article by Roberts et al. regarding DDT use and malaria in South America (1) correctly observes that health policy makers have shifted the emphasis of malaria control programs from vector control to case detection and treatment and that malaria control has been woefully underfunded in recent years. However, their conclusions that increased malaria is due to decreased spraying...

anopheles stephensi is the main malaria vector in south of iran. it has been known to be resistant to ddt, malathion and dieldrin. after appearance of resistance the area was treated with propoxur, at the rate of 2 g/m2 twice a year for 14 successive years. this species is still susceptible to propoxur. in order to forecast the possibility of development of propoxur resistance in an.stephensi, ...