نتایج جستجو برای: cyclin b1

تعداد نتایج: 41655  

Journal: :Journal of virology 2005
Clare E Davy Deborah J Jackson Kenneth Raj Woei Ling Peh Shirley A Southern Papia Das Rina Sorathia Peter Laskey Kate Middleton Tomomi Nakahara Qian Wang Phillip J Masterson Paul F Lambert Scott Cuthill Jonathan B A Millar John Doorbar

Human papillomavirus type 16 (HPV16) can cause cervical cancer. Expression of the viral E1 E4 protein is lost during malignant progression, but in premalignant lesions, E1 E4 is abundant in cells supporting viral DNA amplification. Expression of 16E1 E4 in cell culture causes G2 cell cycle arrest. Here we show that unlike many other G2 arrest mechanisms, 16E1 E4 does not inhibit the kinase acti...

Journal: :Oncology reports 2008
Hong Jae Jo Ju Dong Song Kang Mi Kim Yong Hoon Cho Ki Hyung Kim Young Chul Park

Diallyl disulfide (DADS), a major organosulfur compound of garlic oil, is known to have an anticancer effect on human cancer cells. However, the exact mechanisms of this anticancer activity remain unclear. Here, we investigate the effects of DADS on cell cycle progression in human colon cancer HCT-116 cells by exploring the role played by regulatory molecules such as p53 and cyclin B1. Treatmen...

Journal: :Cancer research 2000
M Park H D Chae J Yun M Jung Y S Kim S H Kim M H Han D Y Shin

Recent studies have suggested that p53 regulates the G2 checkpoint in the cell cycle and that this function is required for the maintenance of genomic integrity. In this study, we investigated a regulatory role of p53 specifically in G2-M transition. Human bladder carcinoma cells lacking functional p53 were synchronized at G1-S, which is preceded by p53-mediated G1 arrest. p53 expression in the...

2013
Kejian Shi Qian Jiang Zhushi Li Lei Shan Feng Li JiaJia An Yang Yang Caimin Xu

BACKGROUND Previous studies demonstrated that selenite induced cancer-cell apoptosis through multiple mechanisms; however, effects of selenite on microtubules in leukemic cells have not been demonstrated. METHODS The toxic effect of selenite on leukemic HL60 cells was performed with cell counting kit 8. Selenite effects on cell cycle distribution and apoptosis induction were determined by flo...

2009
Rolf Aamodt Kristin Jonsdottir Solveig Norheim Andersen Johan Bondi Geir Bukholm Ida R. K. Bukholm

Adenocarcinomas of rectum and colon may be different with regard to the cellular biological basis for cancer development. A material of 246 rectal cancers removed surgically at Akershus University Hospital in the years 1992-2000 was investigated and was compared to a material of 219 colon cancers operated on at Akershus University Hospital during the years 1988, 1990 and 1997-2000. There were h...

2005
Angeles Almeida Juan P. Bolaños Sergio Moreno Beatrice Argenti Rita Gallo Lucia Di Marcotullio Elisabetta Ferretti Maddalena Napolitano Sonia Canterini Enrico De Smaele Azzura Greco Maria Teresa Fiorenza Alberto Gulino Valery Grinevich Michael Brecht

Once neurons differentiate, cell-cycle proteins are downregulated, seemingly locking the cell in G0 phase. This suggests very tight control of expression of these proteins. However, increasing evidence suggests that cell-cycle proteins can be reactivated and contribute to cell demise. For example, the Cdk1– cyclin B1 complex can be reactivated in Alzheimer’s disease. The E3-ubiquitin ligase ana...

Journal: :The Journal of Cell Biology 1999
Jonathan D. Moore Jing Yang Ray Truant Sally Kornbluth

Reversible phosphorylation of nuclear proteins is required for both DNA replication and entry into mitosis. Consequently, most cyclin-dependent kinase (Cdk)/cyclin complexes are localized to the nucleus when active. Although our understanding of nuclear transport processes has been greatly enhanced by the recent identification of nuclear targeting sequences and soluble nuclear import factors wi...

Journal: :PLoS ONE 2007
Vincenzo D'Angiolella Luca Palazzo Concetta Santarpia Vincenzo Costanzo Domenico Grieco

M-phase Promoting Factor (MPF; the cyclin B-cdk 1 complex) is activated at M-phase onset by removal of inhibitory phosphorylation of cdk1 at thr-14 and tyr-15. At M-phase exit, MPF is destroyed by ubiquitin-dependent cyclin proteolysis. Thus, control of MPF activity via inhibitory phosphorylation is believed to be particularly crucial in regulating transition into, rather than out of, M-phase. ...

2016
Michael Brandeis

The spindle assembly checkpoint arrests mitotic cells by preventing degradation of cyclin B1 by the anaphase-promoting complex/cyclosome, but some cells evade this checkpoint and slip out of mitosis. Balachandran et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601083) show that the E3 ligase CRL2ZYG11 degrades cyclin B1, allowing mitotic slippage.

2012
Daan van Abel Omar Abdul-Hamid Marie van Dijk Cees B. M. Oudejans

BACKGROUND In this study we investigated the involvement of the transcription factor STOX1A in the regulation of the cell cycle. METHODOLOGY/PRINCIPAL FINDINGS We found that several major cell cycle regulatory genes were differentially expressed upon STOX1A stimulation and knockdown in the neuroblastoma cell line SH-SY5Y. This includes STOX1A dependent differential regulation of cyclin B1 exp...

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