Background Checkpoint inhibitors (CPIs) have revolutionized the treatment of malignant melanoma. Although melanoma patients may experience deep and durable clinical responses to CPI treatment, majority develop disease progression requiring additional therapy. Combining CPIs with therapeutic cancer vaccines augment anti-tumor immune response thus improve outcomes. UV1 is a vaccine based on synth...

Recent publications have reached con icting conclusions on wheather allowing users to have unlimitted free access for downloading music and lms is bene tial or not for the content provider industrty. Not only do models di er in their conclusions, but there has also not been an agreement on the validity of data on the impact of free access to music and lms using P2P on the pro ts of CPIs and on ...

Cyclophilins are peptidyl-prolyl cis/trans isomerases important in the proper folding of certain proteins. Mounting evidence supports varied roles of cyclophilins, either positive or negative, in the life cycles of diverse viruses, but the nature and mechanisms of these roles are yet to be defined. The potential for cyclophilins to serve as a drug target for antiviral therapy is evidenced by th...

background:  clavicle fractures are common and usually heal without complications. in this study, we evaluated the outcomes of non-operative versus operative management of displaced fractures.   methods:  in a prospective clinical trial study, sixty-five patients with displaced clavicle mid-shaft fractures were nonrandomly divided in two treatment groups. the first group underwent non-operative...

background: some studies have shown the possible role of protein‑energy malnutrition (pem) in persistence of endemic goiter in iodine replenished areas. the present study was conducted to assess the association between pem and goiter in schoolchildren of isfahan, iran. methods: in a cross‑sectional study using multistage cluster random‑sampling, 2331 schoolchildren with age ranged from 6‑13 yea...

Statistical offices use the matched models method to compile consumer price indices (CPIs) to measure inflation. Price collectors record the prices of a sample of models or varieties of selected products existing in period t, and then continue to record the prices of these same matched models in subsequent periods t+n. The matched models method is designed to control for quality changes by ensu...

a correlational study was conducted to investigate the relationship between me duration of labor stages and the   newborn 's apgar score in women admitted to imam khomeini hospital (sari 1994).   a total of 1 20 primigravida women admitted for delivery wert' selected sequentially. the tool was a checklist   consisting of three parts . the first part inquired as to certain demographic ...