AIMS The aim of the present study was to evaluate the cicatricial repair of a corneal artificial perforation in rats with 10-0 nylon suture, N-butyl-2-cyanoacrylate (NBCA) adhesive, or NBCA + methacryloxysulfolane (NBCA-MS) adhesive through microscopic and histological assays. METHODS Twenty Wistar rats were randomly divided into 4 groups each containing 5 rats: (1) control group (corneal tra...

PURPOSE Maintenance of avascularity of the normal cornea and control of neovascularization during wound healing depend on a balance of angiogenic and antiangiogenic factors. The purpose of this paper is to determine the ability of corneal cells to convert plasminogen to angiostatins and to compare these products with those made by intact corneas. METHODS RT-PCR was performed using plasminogen...

The standard treatment for pterygium was surgical excision with bare sclera technique which was associated with a high recurrence rate. Therefore adjunct treatment options are used to reduce this recurrence, such as the use of beta radiation, conjunctiva auto graft, amniotic membrane grafting and mitomycin C (1,2). Pterygium recurrence is one of the challenging problem facing ophthalmologists d...

PURPOSE To report the clinical outcomes of deep anterior lamellar keratoplasty (DALK) when sterile gamma-irradiated acellular corneal tissues (VisionGraft) are used in combination with amniotic membrane transplantation (AMT) for intractable ocular surface diseases. METHODS The medical records of fifteen patients who had DALK with AMT were retrospectively reviewed. Indications for surgery incl...

PURPOSE Vascular endothelial growth factor (VEGF) is essential for neovascularization, but the use of anti-VEGF therapies to inhibit neovascularization may influence epithelial wound healing. Here, the effects of bevacizumab on corneal epithelial wound healing time in rabbit models, cell proliferation, and expression of integrins in human corneal epithelial and fibroblast cells were evaluated. ...

corneal neovasculariuulon (cnj1 can cause significant visual loss. the kinetics of endothelial cells durin{: microvascular growth were studied usinga model of alkaline cauteriuuion-induced neovascularization ofthe 40 rabbits cornea. changes in dna synthetic activity of endothelial cells during neovasculanuuion were assessed by autoradiographic studyojjjl_tdr incorporation, in vivo and in vitro....

INTRODUCTION AND PURPOSE Various conditions may cause vascularization of the normally avascular cornea. The aim of the present study was to create a reproducible experimental model that could enable the investigation of the phenomena leading to corneal vascularization. This involved creating a software to record the experimental data, enabling a subsequent digital analysis based on the growth m...

The purpose of this study was to investigate the effects of minocycline on alkali burn-induced corneal neovascularization (CNV). A total of 105 mice treated with alkali burns were randomly divided into three groups to receive intraperitoneal injections of either phosphate buffered saline (PBS) or minocycline twice a day (60 mg/kg or 30 mg/kg) for 14 consecutive days. The area of CNV and corneal...