Polysaccharide-based carriers have become attractive materials for the delivery of therapeutics targeting colon. Ferulated arabinoxylans (AX)—polysaccharides with gelling and antioxidant capacities that can be degraded by colonic microbiota—are ideal candidates use as oral drug systems [1]. Recently, AX-based microspheres demonstrated potential applications colon-targeted [2,3]. The non-cytotox...

Stercoral perforation of the colon, though rare, is associated with high mortality. Review of the literature identified only three prior cases reported during pregnancy. We report a case on a multiparous female presenting at 31 weeks of gestation with acute abdominal pain. Computed tomography suggested a sigmoid colon perforation. An urgent exploratory laparotomy was performed where feculent pe...

PURPOSE: The objective of the present study is to develop colon targeted drug delivery systems for sennosides using guar gum as a carrier. METHODS: Matrix tablets containing various proportions of guar gum were prepared by wet granulation technique using starch paste as a binder. The tablets were evaluated for content uniformity and in vitro drug release study as per BP method. T50 % value from...

The main objective of the present study was to develop colon targeted drug delivery systems for Nitrofurantoin using guar gum as a carrier. Matrix tablets containing various proportions of guar gum were prepared by wet granulation technique using starch paste as a binder. The in-vitro drug release study was undertaken at 37±0.5°C in 0.1N Hcl for 2 hr; followed by pH 7.4 phosphate buffer (3hr) f...

Abstract: Background: Inflammatory bowel disease (IBD) is a chronic inflammatory of large intestine consisting ulcerative colitis and Crohn’s disease. Mesalamine first line drug use for the treatment but it has drawback low water solubility permeability. In addition, oral delivery to colon faces problem gastric degradation thus increases dose size frequency. Objectives: The present study was ai...

Local delivery to the lower gut treat diseases of colon has become a topic special attention. Tissue exposure locally acting agents is not represented by plasma concentrations. Therefore, reliable methods measure tissue uptake at primary site action (e.g., epithelial layer or lamina propria) are vital. This work investigates suitability mass spectrometry imaging (MSI) in quantitatively visualiz...

Curcumin, obtained from curcuma longa, has been the subject of decades scientific investigation on its therapeutic usefulness. It is reported to possess several properties, which anti-colon cancer interest in this review. Clinically however, curcumin yet firm up place among established contenders. We aimed systematically review prevailing clinical evidence role colon treatment. The drawing lite...

Targeting hypoxia-sensitive pathways has recently been proposed as a new therapeutic approach to the treatment of intestinal inflammation. HIF-hydroxylases are enzymes which confer hypoxic-sensitivity upon the hypoxia-inducible factor (HIF), a major regulator of the adaptive response to hypoxia. Previous studies have shown that systemic (intraperitoneal) administration of hydroxylase inhibitors...

Targeted delivery of drugs is required to efficiently treat intestinal diseases such as colon cancer and inflammation. Nanoparticles could overcome challenges in oral administration caused by drug degradation at low pH and poor permeability through mucus layers, and offer targeted delivery to diseased cells in order to avoid adverse effects. Here, we demonstrate that functionalization of mesopo...

Biopolymers are promising materials in the delivery of protein drugs due to their compatibility, degradation behavior, and nontoxic nature on administration. On suitable chemical modification, these polymers can provide better materials for drug delivery systems. Nanostructured drug carriers allow the delivery of not only small-molecule drugs but also of nucleic acids and proteins. The use of b...