Brain and other central nervous system (CNS) tumors are among the most fatal cancers account for substantial morbidity mortality in United States. Population-based data from Central Tumor Registry of States (a combined set National Program Cancer Registries [NPCR] Surveillance, Epidemiology, End Results [SEER] registries), NPCR, Vital Statistics System SEER program were analyzed to assess conte...

Vesicular stomatitis virus (VSV), an enveloped, nonsegmented, negative-stranded RNA virus, is being tested by several laboratories as an antitumor agent. Unfortunately, viral infection of the central nervous system (CNS) has been observed by many groups following administration to tumor-bearing animals. In rodents, VSV encephalitis is characterized by weight-loss, paralysis, and high mortality....

Lymphomas, and their different radiological presentations have motivated recent publications in the Brazilian radiological literature. Primary lymphoma of the central nervous system (CNS) is becoming increasingly diagnosed both in immunocompetent and immunocompromised patients, and therefore recognition of the several imaging characteristics of such tumor in the conventional and functional imag...

The central nervous system (CNS) high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR) is a recently described molecular entity. We report 3 new CNS HGNET-BCOR cases sharing common clinical presentation and pathologic features. The 3 cases concerned children aged 3 to 7 years who presented with a voluminous mass of the cerebellum. Pathologic features included proliferation of u...

BACKGROUND & AIMS This study is designed for the clinical characteristics and prognostic factors of central neurocytoma (CN). METHODS CN patients from 2004 to 2012 were enrolled from the Surveillance Epidemiology and End Results (SEER) data. Clinical characteristics including age, sex, race, tumor size, tumor number, surgery, and radiation therapy were summarized. Univariate and multivariate ...

Brain metastasis (BM) is increasingly diagnosed in Her2 positive breast cancer (BC) patients. Lack of effective treatment to breast cancer brain metastases (BCBMs) is probably due to inability of the current therapeutic agents to cross the blood-brain barrier. The central nervous system (CNS) response rate in BCBM patients was reported to improve from 2.6%–6% (lapatinib) to 20%–65% (lapatinib i...

Abstract Ependymomas are rare tumors originating from neuroepithelial cells lining the wall of ventricles or central canal spinal cord. While these mainly occur within nervous system (CNS), there occasional reports in children and young adult patients with a primary tumor occurrence outside CNS. sacrococcygeal region have been infrequently described literature no standard care established. We p...

Introduction According to the National Brain Tumor Society, in 2016, approximately 688,096 Americans are living with a brain-tumor (http://braintumor.org/brain-tumor-information/brain-tumor-facts/). It is estimated that approximately 78,000 will be diagnosed, and 16,616 people will die from malignant brain-tumors in 2016. Brain-tumor is challenging to cure and therapy is limited by the lack of ...