.he ability of the cardiac glycosides, ouabain and digoxin, to lower eye pressure-' '' '-• has been ascribed to a primary inhibition of aqueous humor inflow. In the cat, which is the experimental animal of this study, the effect of ouabain on aqueous humor inflow is not clear. The previous report, which indicated that aqueous humor formation of the cat was decreased by ouabain, was based upon r...

T HIS 56-YEAR-OLD MAN WAS ADMITTED to Hahnemann Hospital because of frequent Adams-Stokes attacks. He had experienced an acute myocardial infarction in 1958 and again in 1961. Frequent convulsions occurred in spite of administration of atropine, isoproterenol, and chlorothiazide. On January 3, 1962, an electric pacemaker was implanted on the left ventricle. The following electrocardiographic st...

Three newborn infants are reported who developed severe non-ketotic hypoglycaemia (blood glucose less than 1.1 mmol/l; 19.8 mg/100 ml) within 6 hours of birth. All had inappropriately raised plasma insulin concentrations for the level of glycaemia, and required high rates of glucose infusion (less than 15 mg glucose/kg per minute) to prevent symptoms of hypoglycaemia. Medical treatment (hydroco...

After the introduction of chlorothiazide in 1958,1 as the first of many sulfonamide thiazide diuretics, these orally active diuretics rapidly became the cornerstone for treatment of patients with congestive heart failure (CHF) and other edematous states. These diuretics were also widely adopted for primary or adjuvant antihypertensive drug therapy. Since the beginning, it was recognized that su...

After the introduction of chlorothiazide in 1958,1 as the first of many sulfonamide thiazide diuretics, these orally active diuretics rapidly became the cornerstone for treatment of patients with congestive heart failure (CHF) and other edematous states. These diuretics were also widely adopted for primary or adjuvant antihypertensive drug therapy. Since the beginning, it was recognized that su...

Recently it has been observed that Ca excretion in laboratory rats does not follow a Gaussian distribution, with approximately 10% of them excreting Ca at a rate of 2 SD above the group mean. This phenomenon has been described as spontaneous hypercalciuria (SH). Our studies were designed to define its mechanism. 48 Wistar rats were subjected to metabolic studies to identify SH, prospectively de...