We report a case of hyperthyroidism due to inappropriate thyrotrophin (TSH) secretion in a patient with selective pituitary resistance to thyroid hormone action. Symptoms of hyperthyroidism in patients with this disorder are usually mild, implying some peripheral tissue resistance to the metabolic effects of thyroid hormone. Our patient had unusually severe symptoms, including marked weight los...

Thyrotoxicosis occurs in about 0.2% of pregnancies and is caused most frequently by Graves disease (Burrow, ’85; Kriplani et al., ’94). Graves disease is an autoimmune disorder characterized by the production of antibodies, immunoglobulins of the IgG class, directed against thyroid stimulating hormone (TSH) receptors (Shoenfeld and Schwartz, ’84). This results in the excess production of thyroi...

INTRODUCTION Anti-thyroid drugs (ATDs)-related myopathy is rarely reported in literature, but once developed, it can cause significant morbidity to patient. CASE PRESENTATION A 28-year old Chinese female was treated with carbimazole (CMZ) for Graves' disease with hyperthyroidism. Two weeks later, she developed myalgia and proximal muscle weakness. Investigations showed evidence of myopathy. C...

SINCE thiouracil was introduced to clinical therapeutics in I943, antithyroid treatment for thyrotoxicosis has widely increased and proved more and more effective as the years have passed, partly as the result of experience but also through the use of more effective agents, such as carbimazole and methimazole. It is thus possible now to assess their relative value in comparison with surgical tr...