نتایج جستجو برای: cancer causing genes
تعداد نتایج: 1370181 فیلتر نتایج به سال:
such topics is crucial for the full comprehension of the book. As expected, many of the chapters are heavy on mathematics, for example, when discussing diffraction of X-rays from a crystal or solving the phase problem. However, many illustrations and diagrams are included to facilitate understanding. For interested readers, every chapter is complete with a thorough list of references on all the...
Endothelial cells use an actin-binding protein to retract and allow neutrophils to crawl out of blood vessels, according to a new study by Liu et al. (page 409). Neutrophils must traverse the endothelial cell barrier to migrate out of blood vessels into inflamed or injured tissue. Transendothelial migration, once thought to be controlled primarily by the neutrophil, is now known to be a two-way...
it is clear that colorectal cancer (crc) develops through multiple genetic and epigenetic pathways. these pathways may be determined on the basis of three molecular features: (i) mutations in dna mismatch repair genes, leading to a dna microsatellite instability (msi) phenotype, (ii) mutations in apc and other genes that activate wnt pathway, characterized by chromosomal instability (cin) pheno...
Background:Research has shown that the expression of UBD (Ubiquitin D) is effective in causing cancer. UBD relationship between states with advanced stages of cancer cell differentiation and expression, which probably UBD involved in the progression of carcinogenesis. Overexpression of UBD is related to p53, which subsequently progress to cancer. The purpose of this study is evaluation of Ub...
Prostate cancer, a complex disease, can be relatively harmless or extremely aggressive. To identify candidate genes involved in causal pathways of aggressive prostate cancer, we implemented a systems biology approach by combining differential expression analysis and coexpression network analysis to evaluate transcriptional profiles using lymphoblastoid cell lines from 62 prostate cancer patient...
Background: Characterization of genes and precise assessment of the number of copies are crucial for understanding the basis of emergence, progression, and identification of predictive markers of tumor malignancy. This study aimed to investigate the role of the changes in some central genes in gastric cancer. Materials and Methods: In this experimental study, 30 patients with gastric surgery w...
Background and purpose: Breast Cancer is one of the health problems in every population. The aim of this study was to determine the frequency of BRCA1 and BRCA2 common mutations in women whose mothers were diagnosed with breast cancer. Materials and methods: A case–control study was performed in 109 females (less than 40 years of age) who had mothers with breast cancer. For scanning of...
Carcinogenesis is thought to occur through a combination of mutational and epimutational events that disrupt key pathways regulating cellular growth and division. The DNA methylomes of cancer cells can exhibit two striking differences from normal cells; a global reduction of DNA methylation levels and the aberrant hypermethylation of some sequences, particularly CpG islands (CGIs). This aberran...
We wanted to implement an NGS strategy to globally analyze hereditary cancer with diagnostic quality while retaining the same degree of understanding and control we had in pre-NGS strategies. To do this, we developed the I2HCP panel, a custom bait library covering 122 hereditary cancer genes. We improved bait design, tested different NGS platforms and created a clinically driven custom data ana...
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