نتایج جستجو برای: calf thymus dna

تعداد نتایج: 532599  

F. Manouchehri K. Abdi M. Bonsaii M. Varavipour S. Nafisi

Glycyrrhizin(GL), is a triterpenoid saponin found in glychyrrhiza glabra (liquorice). This compound is a frequently used and very effective drug for the treatment of various malignancies. This study was designed to examine the interactions of glycyrrhizin with calf thymus DNA in aqueous solution at physiological conditions. FTIR spectroscopic method was used to determine the ligand binding mode...

Journal: :Nucleic acids research 1993
A Tanizawa K W Kohn Y Pommier

In this study, we further examined the sequence selectivity of camptothecin in mammalian topoisomerase I cDNA from human and Chinese hamster. In the absence of camptothecin, almost all the bases at the 3'-terminus of cleavage sites are T for calf thymus and wheat germ topoisomerase I. In addition, wheat germ topoisomerase I exhibits preference for C (or not T) at -3 and for T at -2 position. As...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2000
M K Ross B Said R C Shank

Modulation of DNA adduct formation by pre-existing adducts was examined in synthetic oligonucleotides and genomic DNA (calf thymus); genotoxins studied were N-acetoxy-acetylaminofluorene (N-AcO-AAF), aminofluorene (AF), aflatoxin B1-8,9-epoxide (AFB1-8,9-epoxide), and dimethylsulfate (DMS). Oligodeoxynucleotides containing either guanine-C8-AAF (Gua-C8-AAF) or Gua-C8-AF adducts and a neighborin...

Journal: :Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 2006
Ming Guo Qing-Sen Yu

The electrochemical behavior of gatifloxacin (GTFX) and its interaction with natural calf thymus DNA (ctDNA) is investigated by differential pulse voltammetry (DPV) on a carbon paraffined electrode. According to the suggested electrochemical equation, a binding constant of 1.7058 x 10(5) (mol L(-1))(-1) and binding sizes s = 3.09 (base pairs) of GTFX with ctDNA are obtained by nonlinear fit ana...

Cobalt(II)  complexes of isonicotinoyl hydrazones of two series of ligands have been synthesized and characterized on the basis of elemental analyses, molar conductance, magnetic moment, mass, IR, UV spectral data. Electrochemical behavior of ligands and complexes has been investigated by using cyclic voltammetry. Cyclic voltammetric studies reveal that the oxidation/reduct...

ژورنال: دانشور پزشکی 2011
حبیبی, زهره , حسن, زهیر محمد, حسنی, لیلا , مظفری, ولی‌اله , نوری, شکوفه , یوسفی-محمدی, مریم -مهدی ,

Background and Objective: To evaluate interaction of salvigenin with DNA and the molecular mechanism of its anti-cancer effect. Materials and Methods: Salvigenin from Tanacetum canescens and DNA from calf thymus were isolated and purified. Then, salvigenin interaction with DNA in Tris buffer (0.05 M, pH equal to 4.7 and the temperature at 25 °C) was studied by different methods. Results and Con...

Journal: :The Journal of biological chemistry 1973
M Bustin B D Stollar

Antibodies to chromatographically purified rat thymus Fl histone subfractions were induced in rabbits by immunization with histone-RNA complexes. The immunological relatedness between each of the rat thymus Fl subfractions and subfractions derived chromatographically from calf thymus and rat liver Fl was determined by quantitative microcomplement fixation. The various rat thymus peaks elicited ...

Journal: :Molecules 2008
Yoshinobu Ishikawa Naoki Yamakawa Tadayuki Uno

Spectroscopic, viscometric, and molecular docking analysis of binding of cationic bis-porphyrins linked with p- or m-xylylenediamine (H(2)pXy and H(2)mXy) and their zinc(II) complexes (ZnpXy and ZnmXy) to duplex DNA are described. H(2)pXy and H(2)mXy bound to calf thymus DNA (CTDNA) stronger than unichromophoric H(2)TMPyP, and showed exciton-type induced circular dichroism spectra of their Sore...

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