The effects of C-Phycocyanin (C-PC), a biliprotein from Spirulina platensis on the regulation of multidrug resistance-1 (MDR1), a poly glycoprotein in human hepatocarcinoma cell line, HepG2 were reported. The results revealed that a significant down regulation of MDR1 expression in C-PC treated HepG2 cells was through reactive oxygen species and cyclooxygenase-2 (COX-2) mediated pathways. C-PC ...

objective: the present study was carried out to study the relationship between sensation seeking and social skills in two groups of school age patients down-syndrome (ds) and autism disorder (ds).  methods: this is a descriptive-analytic and correlation study in which all participants were of primary school age (10 to 13 years) with down-syndrome and autism disorder of autism spectrum disorder ...

conclusion the low prevalence of the nb absence in normal fetuses in the present study is compatible with the larger size of the nb in iranian people compared to other communities. meanwhile, the reference range of the nb length in normal iranian fetuses was established so that basic data could be recorded for further studies regarding the absence or presence of the nb in screening for chromoso...

background and objectives: the prevalence of diabetes mellitus (insulin resistance) in individuals with down's syndrome is more than healthy people, which is possibly because of the high prevalence of obesity among them. adiponectin is one of adipose tissue-secreted adipocytokines, which plays a role in pathogenesis of obesity and insulin resistance. this study was carried out with the aim of d...

the photoanthropometric method was used to study the facial features in 136 iranian children with down syndrome, aged 4 to 14 years. nineteen parameters were investigated and compared to an age related control group of 100 normal iranian children. the obtained measurements were related to reference values in the same faces. the normal range was defined by age related index values between the 20...

objectives: down syndrome is the most common chrosomal disorder in which the fine and gross motor skills due to lack of proper sensory experience are disturbed. the role of dexterity in activity of daily living, interaction with environment and independency is quiet crucial in down syndrome. therefore, the aim of this study was to investigate the effects of simultaneous application of superfici...

Growth arrest and differentiation of leukemic cells by phorbol 12-myristate 13-acetate (PMA) is accompanied by p53-independent activation of p21WAF1/CIP1 and c-myc down-regulation. We show that despite p21 induction in 7 of 12 human cancer cell lines treated with PMA, growth inhibition was observed only in two cell lines (SKBr3 breast and LNCaP prostate cancer cells). Treatment of SKBr3 and LNC...