OBJECTIVE The aim of the present study was to investigate whether patients with persistent pain after breast cancer treatment show an enhanced and slowed dominant alpha activity in their electroencephalogram (EEG) recorded during rest in comparison with patients that also had undergone breast cancer treatment but do not have pain. METHODS The spontaneous EEG was recorded during rest and befor...

Background and aim: Afterpain is a common phenomenon after vaginal delivery. Any factor that causes a delay in the process of uterus sub involution and consequently returning its size to pre-pregnancy status could affect the severity of afterpain. This study aimed to investigate the factors related to afterpain in multiparous women delivered in 17-Shahrivar Hospital, Mashhad, Iran.  Methods: In...

the aim of this investigation is to compare the effect of applying two transcutaneous electrical nerve stimulation (tens) current with different frequencies (2 hz & 100 hz) on hoffmann reflex recorded from gastrosoleus muscle of healthy people. forty female subjects between 20 to 30 years of age were participated in this quasi-experimental design. twenty of them were exposed to the 100 hz curre...

background: motor function impairment occurs in approximately two-thirds of patients with subcortical stroke. repetitive transcranial magnetic stimulation (rtms) is a noninvasive technique for modulating cortical excitability. objectives: the present study was designed for assessing the efficacy of high-frequency rtms (5 hz) on ipsilesional primary motor cortex in patients with subcortical stro...

Metformin, a Type II diabetic treatment drug, which inhibits transcription of gluconeogenesis genes, has recently been shown to lower the risk of some diabetes-related tumors, including breast cancer. Recently, "cancer stem cells" have been demonstrated to sustain the growth of tumors and are resistant to therapy. To test the hypothesis that metformin might be reducing the risk to breast cancer...

The emerging paradigm of "oncogene addiction" has been called an Achilles' heel of cancer that can be exploited therapeutically. Here, we show that integrin-linked kinase (ILK), which is either activated or overexpressed in many types of cancers, is a critical regulator of breast cancer cell survival through the protein kinase B (PKB)/Akt pathway but is largely dispensable for the survival of n...