Faithful segregation of the genetic material during the cell cycle is key for the continuation of life. Central to this process is the assembly of a bipolar spindle that aligns the chromosomes and segregates them to the two daughter cells. Spindle bipolarity is strongly dependent on the activity of the homotetrameric kinesin Eg5. However, another kinesin, Kif15, also provides forces needed to s...

The spindle assembly checkpoint (SAC) delays mitotic progression until all sister chromatid pairs achieve bi-orientation, and while the SAC can maintain mitotic arrest for extended periods, moderate delays in mitotic progression have significant effects on the resulting daughter cells. Here we show that when retinal-pigmented epithelial (RPE1) cells experience mitotic delay, there is a time-dep...

The independence of positive and negative affect has been heralded as a major and counterintuitive finding in the psychology of mood and emotion. Still, other findings support the older view that positive and negative fall at opposite ends of a single bipolar continuum. Independence versus bipolarity can be reconciled by considering (a) the activation dimension of affect, (b) random and systema...

The complex relationship between the use of antidepressants and suicidal behaviour is one of the hottest topics of our contemporary psychiatry. Based on the literature, this paper summarizes the author's view on antidepressant-resistant depression and antidepressant-associated suicidal behaviour. Antidepressant-resistance, antidepressant-induced worsening of depression, antidepressant-associate...

This paper is concerned with a particular kind of Korean relative clause constructions that contain possessive specifier gaps, as opposed to complement or adjunct gaps. Those relative clauses have been known to violate Ross's Complex NP Constraint, and various attempts have been made to account for the apparent island violations. This paper argues that those relative clauses have possessive spe...

DIALOGS (Dialog-based Inductive and Abductive LOGic program Synthesizer) is a schema-guided synthesizer of recursive logic programs; it takes the initiative and minimally queries a (possibly computationally naive) specifier for evidence in her/his conceptual language. The specifier must know the answers to such simple queries, because otherwise s/he wouldn’t even feel the need for the synthesiz...

Bresnan's Endocentric Mapping Principles (Bresnan, 2001) are used as diagnostics to demonstrate that the Mandarin relative clause structure is an endocentric one, in which the particle de is the sole functional and c-structural head, and the modified noun is one of two specifiers. The relative clause occupies a phraseinitial specifier position associated with a Modifier DF, and the final NP occ...