Recent results of advanced experiments with sophisticated measurements of cosmic rays in the energy range of the so called knee at a few PeV indicate a distinct knee in the energy spectra of light primary cosmic rays and an increasing dominance of heavy ones towards higher energies. This leads to the expectation of knee-like features of the heavy primaries at around 100 PeV. To investigate in d...

Hypoxia-inducible factor 1 (HIF-1) is a major mediator of the hypoxic response involved in tumor progression. We had earlier described the interaction between septin 9 isoform 1 (SEPT9_i1) protein and the oxygen-regulated subunit, HIF-1α. SEPT9_i1 is a member of the conserved family of GTP-binding cytoskeleton septins. SEPT9_i1 stabilizes HIF-1α and facilitates its cytoplasmic-nuclear transloca...

Alternanthera mosaic virus (AltMV) triple gene block 3 (TGB3) protein is involved in viral movement. AltMV TGB3 subcellular localization was previously shown to be distinct from that of Potato virus X (PVX) TGB3, and a chloroplast binding domain identified; veinal necrosis and chloroplast vesiculation were observed in Nicotiana benthamiana when AltMV TGB3 was over-expressed from PVX. Plants wit...

La dinámica que subyace en los extremismos tiene como rasgo común la exclusión del otro a través discurso de odio. Una las claves para prevención extremismo violento (PEV) apunta trabajar desde políticas públicas prejuicios y estereotipos sustentan ideas conforman el discriminatorio. Este estudio expone un proyecto educativo marco estrategia PEV UNESCO literatura. propuesta se articula alrededo...

The IceCube experiment at South Pole consists of two detector components the IceTop air shower array on the surface and the neutrino telescope at depths from 1450 to 2450 meters below. Currently, 26 IceTop stations and 22 InIce strings are deployed. With the present size of the IceTop array, it is possible to measure cosmic rays with energies ranging from 0.5 PeV to 100 PeV. Coincident events b...

Genes normally resident in euchromatic domains are silenced when packaged into heterochromatin, as exemplified in Drosophila melanogaster by position effect variegation (PEV). Loss-of-function mutations resulting in suppression of PEV have identified critical components of heterochromatin, including proteins HP1, HP2, and histone H3 lysine 9 methyltransferase. Here, we demonstrate that this sil...

Although the Drosophila Y chromosome is degenerated, heterochromatic, and contains few genes, increasing evidence suggests that it plays an important role in regulating the expression of numerous autosomal and X-linked genes. Here we use 15 Y chromosomes originating from a single founder 550 generations ago to study the role of the Y chromosome in regulating rRNA gene transcription, position-ef...

Background: The pericardial effusion volume (PEV) does not possess a known regular shape. Therefore, the standard methods for volume estimation based on 2-D echooardiography can not be / / applied. This study was conducted to evaluate a new computer algorithm for acoustic quantification of PEV. Methods: Borders of the pericardial sac and the heart were identified either by hand tracing or with ...

A review of current status of theoretical paradigm and results of direct and indirect experiments to study cosmic rays through the knee region are presented and discussed. There is general agreement that the knee is around a PeV and that it reflects a rigidity cutoff. The composition of cosmic rays in the knee region is mixed and changing with energy. The two direct experiments, JACEE and RUNJO...