نتایج جستجو برای: beta thalassemia major
تعداد نتایج: 795743 فیلتر نتایج به سال:
Background Thalassemia is a common hereditary anemia in humans, and beta thalassemia represents a group of recessively inherited hemoglobin disorders first described by Cooley and Lee and characterized by the abnormal synthesis of β-globin chain. The homozygous state results in severe anemia, which needs regular blood transfusion. Although such treatments increase the patient's life span, a var...
Aim of the Study: To assess maternal and fetal outcome in pregnant patients with Beta-thalassemia major. Material and Methods: A prospective study of pregnancy outcome of women with beta-thalassemia major admitted to the High Risk Pregnancy Unit, Department of Obstetrics and Gynecology, Kasr Al Aini hospital over the period of March 2010 to October 2013. Results: A total of 22 pregnant patients...
beta-Thalassemia and sickle cell disease both display a great deal of phenotypic heterogeneity, despite being generally thought of as simple Mendelian diseases. The reasons for this are not well understood, although the level of fetal hemoglobin (HbF) is one well characterized ameliorating factor in both of these conditions. To better understand the genetic basis of this heterogeneity, we carri...
BACKGROUND Beta thalassemia is one of the most common genetic disorders in the world. The aim of this study was to determine the frequency, characteristics, and pattern of malignancies in patients with beta thalassemia major (BTM) and beta thalassemia intermedia (BTI) in Iran. METHODS We conducted a multicenter study via a retrospective chart review of patients with BTM and BTI between 2002 a...
In this study, it was aimed to identify the problems related disease process of 12-18 years old children with Beta-Thalassemia Major and examine effectiveness individualized empowerment education regarding these needs. This research is a mixed-type study. first stage, determine needs BTM in relation process; phenomenological method used. second pre/post-test controlled quasi-experimental used s...
Abstract Background Hypothyroidism usually appears in the second decade of life and is thought to be associated with iron overload in patients with thalassemia major. This study aimed to evaluate thyroid dysfunctions in patients with beta-thalassemia major. Materials and Methods This research is a descriptive – cross sectional study, carried out in 2009 to assess thyroid function in 100 p...
Background :Highserum level of cancer antigen 15.3 (CA15.3) has been reported in some malignant and nonmalignant conditions including thalassemia major which could have been resulted from ineffective erythropoiesis. We aimed to evaluate the serum level of CA15.3 in carriers of beta-thalassemia by comparing them with cancer patients and healthy individuals. Methods : This cross-sectional stu...
Objectives: To determine the molecular characterisation of beta-thalassemia major patients, pattern endocrine complications and its association with haemoglobin subunit beta gene variants. Method: The cross-sectional study was conducted from November 2021 to 2022 after approval ethics review committee Liaquat University Medical Health Sciences, Jamshoro, Pakistan, comprised 88 patients thalasse...
Thalassemia is a congenital hemolytic disorder caused by a partial or complete deficiency of alpha- or beta-globin chain synthesis. Homozygous carriers of beta-globin gene defects suffer from severe anemia and other serious complications from early childhood. The disease is treated by chronic blood transfusion. However, this can cause severe iron overload resulting in progressive organ failure....
Received May 2007 Accepted September 2007 INTRODUCTION Priapism (painful erection longer than 6 hours) is an uncommon disease that is almost always due to thromboembolic problems. It may occur at any age. The predisposing factors for priapism include thromboembolic disorders such as sickle cell anemia (SCA, the most common cause), sicklebeta-thalassemia, diseases of the central nervous system a...
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