Belt-positioning booster seats are recommended for children who use vehicle seat belts as primary restraints but who are too small to obtain good belt fit. Previous research has shown that belt-positioning boosters reduce injury risk, but the belt fit produced by the wide range of boosters in the US market has not previously been assessed. The present study describes the development of a method...

The geographical distribution of Alpha and Beta-Thalassemias differ markedly. Alpha-Thalassemia being particularly prevalent in Southeast Asia and Beta-Thalassemia in the Mediterranean basin. Thalassemia syndromes are common in Saudi Arabia: the Beta-Thalassemia genes occur with variable frequency in different regions of Saudi Arabia and both B+ and Bo thalassemia have been reported. Alpha-Thal...

Combined megaloblastic anemia with thalassemia is easily masked because of the loss of macrocytosis. We performed a retrospective study to compare the major parameters in 4 groups of subjects in order to show the characteristics of patients with megaloblastic anemia and thalassemia. Group A comprised 9 patients with megaloblastic anemia and tha-lassemia, group B comprised 10 patients with uncom...

Abstract Background ?-thalassemia is relatively endemic in Guizhou province of southwestern China. To predict the clinical manifestations ?-globin gene aberration for genetic counseling, we examined prevalence triplication and genotype–phenotype correlation this subpopulation Methods A cohort 7644 subjects was selected from nine ethnicities covering four regions Peripheral blood collected each ...

Bệnh Thalassemia là bệnh di truyền phổ biến nhất trên thế giới. Ước tính tỷ lệ mang gen thalassemia trung bình trong cộng đồng tất cả các dân tộc Việt Nam 13,8%. β-thalassemia thể nặng có biểu hiện thiếu máu tan nặng, ảnh hưởng đến khả năng sống, chất lượng sống của người bệnh. Việc sàng lọc, chẩn đoán sớm bệnh, đóng vai trò quan trọng giúp hạn chế sinh ra trẻ mắc β-thalassemia. Nhiều kỹ thuật ...

We evaluated the use of an HPLC method for screening hemoglobins in cord blood. We studied the genotype frequencies of the structural hemoglobin variants HbS and HbC and the synthesis variants alpha- and beta(+)-thalassemia in babies born on Curaçao. During three months, 67.2% of all (748) newborns were screened: 122 (24.3%) had an abnormal hemoglobin pattern, of which 53 (43.4%) had a hemoglob...

Hemoglobin E (HbE) β-thalassemia is the most common severe thalassemia syndrome across Asia, and millions of people are carriers. Clinical heterogeneity in HbE β-thalassemia is incompletely explained by genotype, and the interaction of phenotypic variation with hepcidin is unknown. The effect of thalassemia carriage on hepcidin is also unknown, but it could be relevant for iron supplementation ...

Thalassemia is defined as a condition in which reduced rate of synthesis of one or more of the globin chains leads to defective haemoglobin production. Of the two major types, in alphathalassemia, occhain synthesis is absent or diminished and in beta-thalassemia, B-chain synthesis is absent or diminished. In B-thalassemia, anaemia occurs due to reduced B globulin, which in turn reduces HbA resu...

BACKGROUND The Gγ-158(C→T) polymorphism plays important function in the clinical variability of HbE/β-thalassemia. There is little known about Gγ-158(C→T) polymorphism in HbE/β-thalassemia major in Southern China. This study aimed to explore the association between HbE/β-thalassemia major and this polymorphism in Southern China. METHODS AND RESULTS The frequency of the Gγ-158(C→T) polymorphis...

ResearcherS used two behavioral prompts to compare increases in safety belt use: a Click It or Ticket prompt or a Flash-for-Life prompt. Participants were 1,822 unbuckled drivers exiting two student parking lots of a large university. Research assistants identified unbuckled drivers, flashed one of the two prompts, and recorded whether drivers buckled after the prompt and the drivers' facial ex...