PURPOSE Infantile nystagmus syndrome (INS) is characterized by involuntary eye oscillations that can assume different waveforms. Previous attempts to uncover reasons for the presence of several nystagmus waveforms have not led to a general consensus in the community. Recently, we characterized the belladonna (bel) zebrafish mutant strain, in which INS-like ocular motor abnormalities are caused ...

Astragaloside is a saponin widely used in traditional Chinese medicine and has been reported to be a potent multidrug resistance (MDR) reversal agent. The present study investigated the role of astragaloside Ⅳ (ASIV) in the regulation of P-glycoprotein (P-gp, encoded by the mdr1 gene) and its effect on the reversal of MDR. The activity of ASIV was evaluated using human hepatic cancer cells Bel-...

Background Patients with SLE are recommended to continue the maintenance therapy as less glucocorticoid possible.1) However, tapering often results in recurrence of SLE. Current reports suggested that adding BEL standard could lead reduction and SLE.2) Objectives The aim this study is evaluate efficacy safety co-treatment Methods Fourteen patients receiving were enrolled study. Dose prednisolon...

A new oleanane-type saponin oleiferasaponin C6 (OSC6) was isolated and identified from Camellia oleifera seeds through NMR, HR-ESI-MS, and GC-MS spectroscopic methods. This new oleanane-type saponin exhibits potent cytotoxic activities on five human cancer cell lines (BEL-7402, BGC-823, MCF-7, HL-60 and KB), especially in HL-60 and BEL-7402 cell lines. The action mechanism of the anti-cancer ac...

BEL is a probabilistic description logic (DL) that extends the light-weight DL EL with a joint probability distribution over the axioms, expressed with the help of a Bayesian network (BN). In recent work it has been shown that the complexity of standard logical reasoning in BEL is the same as performing probabilistic inferences over the BN. In this paper we consider conjunctive query answering ...

The docosahexaenoic (DHA), a ω-3 fatty acid, could play a beneficial inhibition of the incidence and progress of a series of human diseases including cancer. It has been report that DHA is involved in cell apoptosis. Recent studies show that the signal transduction pathway links with bcl-2, bax, caspase-3 and MMP-9 molecules. Therefore, we tested the relationship between DHA and cell apoptosis ...

Summary Biological Expression Language (BEL) assembles knowledge networks from biological relations across multiple modes and scales. Here, we present PyBEL; a software package for parsing, validating, converting, storing, querying, and visualizing networks encoded in BEL. Availability and implementation PyBEL is implemented in platform-independent, universal Python code. Its source is distri...

Marine Lacomme, Laurence Liaubet, Fabienne Pituello et Sophie Bel-Vialar 4 Centre de Biologie du Développement, CNRS UMR5547, Toulouse, France 31062 Toulouse, 5 Laboratoire de Génétique Cellulaire, INRA UMR444, Castanet Tolosan France 6 7 8 Corresponding author: Sophie Bel-Vialar [email protected] 9 Co-Corresponding author: Fabienne Pituello [email protected] 10 11 Runni...

We introduce the new probabilistic description logic (DL) BEL, which extends the light-weight DL EL with the possibility of expressing uncertainty about the validity of some knowledge. Contrary to other probabilistic DLs, BEL is designed to represent classical knowledge that depends on an uncertain context; that is, some of the knowledge may hold or not depending on the current situation. The p...