نتایج جستجو برای: araf
تعداد نتایج: 130 فیلتر نتایج به سال:
A simple biochemical method to isolate mRNAs pulled down with a transfected, biotinylated microRNA was used to identify direct target genes of miR-34a, a tumor suppressor gene. The method reidentified most of the known miR-34a regulated genes expressed in K562 and HCT116 cancer cell lines. Transcripts for 982 genes were enriched in the pull-down with miR-34a in both cell lines. Despite this lar...
صمغ فارسی یک بسیارقندی اسیدی (میانگین ph 4/4) حاوی مقدار کمی پروتئین (تقریبا w/w %2/0) و ظرفیت جذب آب نسبتا بالا است (به طور متوسط g/g65/12) که از w/w %70 بخش نامحلول و w/w %30 بخش محلول تشکیل شده است. در ضمن، با افزایش غلظت صمغ (1/0 تا w/v %9/0) کشش سطحی محلول های آبی کاهش یافت؛ علاوه براین، منطقه جغرافیایی رویش و رنگ صمغ بر تعداد کمی از شاخص ها تاثیرگذار بودند. در ارتباط با بررسی امولسیون های...
Triple-negative breast cancer (TNBC) is characterized by the absence of expression of estrogen receptor, progesterone receptor, and HER-2. Thirty percent of patients recur after first-line treatment, and metastatic TNBC (mTNBC) has a poor prognosis with median survival of one year. Here, we present initial analyses of whole genome and transcriptome sequencing data from 14 prospective mTNBC. We ...
RAF kinases are major constituents of the mitogen activated signaling pathway, regulating cell proliferation, differentiation and cell survival of many cell types, including neurons. In mammals, the family of RAF proteins consists of three members, ARAF, BRAF, and CRAF. Ablation of CRAF kinase in inbred mouse strains causes major developmental defects during fetal growth and embryonic or perina...
PURPOSE The clinical use of BRAF inhibitors is being hampered by the acquisition of drug resistance. This study shows the potential therapeutic use of the HSP90 inhibitor (XL888) in six different models of vemurafenib resistance. EXPERIMENTAL DESIGN The ability of XL888 to inhibit growth and to induce apoptosis and tumor regression of vemurafenib-resistant melanoma cell lines was shown in vit...
Angiogenesis mediated by vascular endothelial growth factor (VEGF) is known to play an important role in regulating cartilage remodelling and endochondral ossification. However, the details of how VEGF signalling mechanisms affect condyle remodelling in response to alterations in functional loading remains unclear. To explore this, eighty 16-day-old male SD rats were divided into two equal grou...
Background: KRAS is the most frequently mutated RAS/RAF family member (mutated in 15% of cancers), followed by BRAF (5%) and NRAS (3%). Several MEK inhibitors (MEKi) are approved for V600E cancers, G12C inhibitor sotorasib non-small cell lung cancer (NSCLC). However, there still a need agents targeting other mutations (mt), including G12 V which ∼7%, ∼9% ∼19% NSCLC, colorectal pancreatic respec...
Background: Tuberculosis (TB) remains a major public health concern despite being curable and preventable disease. The treatment of TB using cocktail drugs over period six months under the directly observed short-course strategy has led to reduction in cases but is plagued by some challenges that leads unsuccessful or poor outcomes, which can ultimately result spread infections, development dru...
Background: Thyroid tumors represent 1–3% of canine cancers with most classified as follicular carcinomas. Medullary carcinomas arising from c-cells are less frequently diagnosed in both dogs and humans. In comparison, papillary thyroid the common type human cancer (70–80%) 10–15% cases. 2% cases 20% these associated inherited gene mutations RET. Human bear activating BRAF NRAS. Materials Metho...
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