hematopoietic cord blood (cb) stem cell transplantation has more advantages to other cell sources because of lower graft versus host disease (gvhd). interleukin-15(il-15) is an immunoregulatory cytokine, known to enhance cytolytic function of cord natural killer (nk) cells. the aim of this study was to investigate the effect of il-15 on nk cytotoxicity simultaneously in different cell death sta...

      ICD-85 (venom derived peptides) has anti-proliferative effect and anti-angiogenesis activity on cancer cells. This study was performed to test the effect of ICD-85, on Human breast adenocarcinoma (MCF-7) and normal Human Dermal Fibroblasts (HDF) cell lines. In this experimental study, Mitochondrial activity, Neutral red uptake, Lactate dehydrogenase (cell necrosis), and cell morphology we...

Background/Aim: This study was designed to investigate the effect of IL-39 on T24 bladder cancer (BC) cell line survival and growth. Materials Methods: In order assess direct survival, proliferation, apoptosis BC cells, we utilized a clonogenic assay, proliferation caspase-3 activity kits. Potential proliferative apoptotic molecular mechanisms were evaluated by RT-PCR. Results: Treatment cells ...

Sparganii Rhizoma and Curcumae (SRCR) are natural herbs used in traditional Chinese medicine to treat tumors activate blood circulation. Previous studies have shown that SRCR possesses notable antitumor activity; however, the mechanism underlying anticancer activity human oral squamous cell carcinoma (OSCC) has yet be fully elucidated. The risk factors of OSCC include smoking, alcohol consumpti...

background :gelatin and chitosan are known as biodegradable and biocompatible biopolymers.these biopolymers have recently receivedincreasingly more attention for tissueengineering.the aim of this study was to evaluate the toxicity effects of gelatin-chitosan film on bone marrow stromal cell(bmscs) culture in rat.                                                  materials & methods: first, gelat...

objective(s):hypoxia induces cellular oxidative stress that is associated with neurodegenerative diseases. here, the protective effects of ferulic acid (fa) on hypoxia-induced neurotoxicity in pc12 cells were evaluated. materials and methods:we investigated the effect of fa on pc12 cells subjected to hypoxia stress, in vitro. results:fa increased cell viability, prevented membrane damage (ldh r...