نتایج جستجو برای: antiplasmodial activity malaria plasmodium berghei peters test 1
تعداد نتایج: 4201562 فیلتر نتایج به سال:
wALADin1 benzimidazoles are specific inhibitors of δ-aminolevulinic acid dehydratase from Wolbachia endobacteria of filarial nematodes. We report that wALADin1 and two derivatives killed blood stage Plasmodium falciparum in vitro (50% inhibitory concentrations, 39, 7.7, and 12.8 μM, respectively). One of these derivatives inhibited gliding motility of Plasmodium berghei ANKA infectious sporozoi...
background : malaria remains a serious public health problem with significant morbidity and mortal-ity. this study was conducted to identify whether ficolin-a could play an active role of against mala-ria infection. methods : the function of ficolin-a was analyzed in mouse model. the open reading frame of fico-lin-a was cloned from the liver of new born c57bl/6 mice by rt-pcr and then inserted ...
we have previously shown the adjuvant activity of propranolol (prp) (a beta-adrenergic receptor antagonist) using a vaccine model for salmonella typhimurium. in this study prp was used as an adjuvant in combination with plasmodium berghei (p. berghei) whole blood stage (pwbs) antigens. balb/c mice were immunized three times with a 2-week interval, either pwbs vaccine alone or in combination ...
background: characterizing the mechanical properties of brain tissue is deemed important for developing a comprehensive knowledge of the mechanisms underlying brain diseases. mechanical properties of very soft tissues, such as brain until recently have been attracted the attention of researchers because these tissues do not tolerate mechanical loads. the mechanical properties of brain tissue, h...
4-Nerolidylcatechol (1) is an abundant antiplasmodial metabolite that is isolated from Piper peltatum roots. O-Acylation or O-alkylation of compound 1 provides derivatives exhibiting improved stability and significant in vitro antiplasmodial activity. The aim of this work was to study the in vitro inhibition of hemozoin formation, inhibition of isoprenoid biosynthesis in Plasmodium falciparum c...
ETHNOPHARMACOLOGICAL RELEVANCE In Kenya, 22 million people are at risk of malaria, 70% of them are in rural areas and most of these people use traditional plant based medicines to treat malaria. The aim of the study was to escalate documentation, from an earlier study of medicinal plants, traditionally used to treat malaria by the Digo community of Kwale County, taking cognizance of their pharm...
To find a new anti-malarial medicine derived from natural resources, we examined the leaves of 13 common Japanese plants in vitro. Among them, a leaf-extract of Hydrangea macrophylla, a common Japanese flower, inhibited the parasitic growth of Plasmodium falciparum. The IC50 of Hydrangea macrophylla leaf extract to Plasmodium falciparum was 0.18 microg/ml. The IC50 to NIH 3T3-3 cells, from a no...
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