tuberculosis, M. bovis, M. africanum and others, known collectively as the M. tuberculosis complex (MTC) [1]. M. tuberculosis is responsible for more human mortality than any other single microbial species [2]. According to estimates by World Health Organization (WHO), almost 9 million new cases and 1.4 million TB deaths occurred in 2011 [3]. Although there are effective anti-tubercular agents,...

Reports have shown that oleanolic acid (OA), a triterpenoid, exists widely in food, medicinal herbs and other plants, and that it has antimycobacterial activity against the Mycobacterium tuberculosis strain H37Rv (ATCC 27294). In this study it was found that OA had antimycobacterial properties against eight clinical isolates of M. tuberculosis and that the MICs of OA against drug-sensitive and ...

The aim of this study was to use the microtitre alamarBlue assay to investigate and compare the antimycobacterial potential of the lantibiotics nisin and lacticin 3147 against a representative cohort of clinically significant mycobacteria, i.e. Mycobacterium tuberculosis H37Ra, Mycobacterium avium subsp. paratuberculosis (MAP) ATCC 19698 and Mycobacterium kansasii CIT11/06. Lacticin 3147 displa...

Three series of biarylpyrazole imidazole and triazoles are described, which vary in the linker between the biaryl pyrazole and imidazole/triazole group. The imidazole and triazole series with the short -CH2- linker displayed promising antimycobacterial activity, with the imidazole-CH2- series (7) showing low MIC values (6.25-25 μg/mL), which was also influenced by lipophilicity. Extending the l...

The treatment of tuberculosis has become more difficult with the worldwide spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis. Moreover, the prevalence of human disease caused by atypical mycobacteria has also increased in the past two decades and has further complicated the problem of the treatment of mycobacterial infections. It is t...

The present study reveals that the effect of extra cellular protein isolated from Psychrophilic Actinomcetes against clinical pathogens. Totally 13 Actinomycetes were isolated from glacier soil. Among them the genus Streptomycetes and Micromonospora were isolated highly. MM9 medium was used as fermentation medium and the antimicrobial peptide activity was performed by disc diffusion method. Out...

We investigated the antimycobacterial role of myeloperoxidase (MPO), one of the most abundant granule proteins in human neutrophils. Our data indicate that purified MPO, in the presence of hydrogen peroxide, exerts a consistent killing activity against Mycobacterium tuberculosis H37Rv and against a clinical isolate. The activity is time and dose dependent and requires the presence of chloride i...

The aim of present study is to synthesize a series of different p-substituted benzyl thiosemicarbazone and evaluate their cytotoxicity as well as their antimycobacterial activity. The chemical structures have been assigned by micro analysis and spectral data (UV-Vis, IR and H NMR). All the compounds have been tested for their in vitro cytotoxic activity against leukaemia cancer cell line K562 a...