Chemotherapy-induced nausea and vomiting (CINV) prevention is important to reduce overall morbidity financial burden in patients receiving chemotherapy. Severe symptoms the patient's quality of life can interfere with further treatment. The five major forms CINV (ie, acute, delayed, predicted, breakthrough, refractory) often include 5-HT3 receptor antagonists, NK1 various treatments that cortic...

BACKGROUND The aim of this study was to evaluate the efficacy of ondansetron and ramosetron in the reduction of post-operative nausea and vomiting (PONV) associated with patient-controlled analgesia (PCA) after cardiac surgery. METHODS A total of 320 patients scheduled for elective cardiac surgery were enrolled. Patients were randomly assigned to one of four treatment regimens (n=80 in each g...

Many kinase inhibitors, chemotherapeutic agents, antiemetics, antibiotics, and antifungal agents can prolong QT intervals, placing the patient as risk for the life-threatening ventricular arrhythmia Torsade de pointes (Tdp). In addition, common electrolyte imbalances experienced by many patients with cancer compound the risk. Because numerous medications used in oncology and common electrolyte ...

Continuous subcutaneous infusions of drugs by syringe driver are used often and successfully in the terminal care of patients when drugs cannot be given orally. Diamorphine is the opioid of choice because of its high solubility. If other drugs such as antiemetics, anticholinergics, sedatives, or steroids are required they may also be given by syringe driver. This method is particularly useful f...

Postoperative nausea and vomiting (PONV) and pain are two of the major concerns for patients presenting for surgery. The causes of PONV are multifactorial and can largely be categorized as patient risk factors, anaesthetic technique, and surgical procedure. Antiemetics work on several different receptor sites to prevent or treat PONV. This is probably why numerous studies have now demonstrated ...

BACKGROUND Hyperemesis gravidarum (HG) is the most severe form of nausea and vomiting of pregnancy which can have potentially dangerous complications if untreated. Its treatment is basically supportive as the condition itself is self-limiting. The aim of our study was to evaluate maternal characteristics in patients with HG including risk factors and treatment outcome with respect to improvemen...

Correspondence: Christina Ruhlmann Odense University Hospital, Department of Oncology, Sdr. Boulevard 29, DK-5000 Odense C, Denmark Tel +45 6541 3834 email christina.ruhlmann@ouh. regionsyddanmark.dk Abstract: Chemotherapy-induced nausea and vomiting (CINV) are among the most feared and distressing symptoms experienced by patients with cancer. The knowledge of the pathogenesis and neuropharmaco...