The act of emesis is controlled by the vomiting centre in the medulla, which integrates afferent input from the vestibular system, the chemoreceptor trigger zone (CTZ), the cortex and the gut. Nausea and vomiting induced by several cancer chemotherapy agents is often the most distressing side effect of treatment. The mechanism of action of antiemetic is related to blockage of various type of re...

INTRODUCTION Diarrheal diseases are the second leading cause of childhood morbidity and mortality in developing countries and an important cause of malnutrition. An estimated 0.75 million children below 5 years of age die from diarrhea. Vomiting associated with acute gastroenteritis (AGE) is a distressing symptom and limits the success of oral rehydration in AGE leading to an increased use of i...

Nausea and vomiting induced by several cancer chemotherapy agents is often the most distressing side effect of treatment. The mechanisms are quite complex. The vomiting center in the reticular formation can be stimulated by either afferent stimuli from the gastrointestinal tract or by the chemoreceptor trigger zone (e1Z). The latter is probably the primary site for emetic activity of most cance...

Antiemetics play a key role in hematopoietic cell transplantation (HCT). High-dose chemotherapy and total body irradiation (TBI) have high emetogenic potential, vomiting nausea during conditioning regimen thereafter impair oral intake, which can lead to weight loss, hyperglycemia due parenteral nutrition, infectious disease, increased transplant-related mortality. We searched for randomized tri...